PF-05105679

Identifiers
IUPAC name 3-({[(1R)-1-(4-fluorophenyl)ethyl]-(quinoline-3-carbonyl)amino}methyl)benzoic acid
CAS Number	1398583-31-7
PubChemCID	60195662
DrugBank	DB15450
ChemSpider	57871141
UNII	F2B10OFV7Y
ChEMBL	ChEMBL3577885
CompTox Dashboard(EPA)	DTXSID301336742
Chemical and physical data
Formula	C26H21FN2O3
Molar mass	428.463 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@H](C1=CC=C(C=C1)F)N(CC2=CC(=CC=C2)C(=O)O)C(=O)C3=CC4=CC=CC=C4N=C3
InChI InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1 Key:BXNMZRPTQFVRFA-QGZVFWFLSA-N

PF-05105679 is a drug which acts as a potent and selective blocker of theTRPM8ion channel, which is the main receptor responsible for the sensation ofcold. It was developed as a potentialanalgesic, and blocks the sensation of cold in both animals and human trials. It also lowerscore body temperature in small mammals, but does not produce this effect in humans in the normal dosage range.^[1][2][3]

• AMG-333
• RQ-00203078

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