PF-05089771

Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide
CAS Number	1235403-62-9
PubChemCID	46840946
ChemSpider	29411106
UNII	25U4N985O2
ChEMBL	ChEMBL2325014
CompTox Dashboard(EPA)	DTXSID301336085
Chemical and physical data
Formula	C18H12Cl2FN5O3S2
Molar mass	500.34 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
InChI InChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25) Key:ZYSCOUXLBXGGIM-UHFFFAOYSA-N

PF-05089771 is a selective,small-moleculeNa_v1.7 andNa_v1.8voltage-gated sodium channelblocker under development byPfizer as a novelanalgesic.^[1][2][3] As of June 2014, it has completedphase IIclinical trials forwisdom tooth removal andprimary erythromelalgia.^[4]

• List of investigational analgesics

• "PF-05089771".AdisInsight. Springer Nature Switzerland AG.

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