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PEPA (drug)

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PEPA
Clinical data
Other namesPEPA
Legal status
Legal status
Identifiers
  • 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}thio)phenoxy]acetamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H16F2N2O4S2
Molar mass402.43 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
 ☒NcheckY (what is this?)  (verify)

PEPA is asulfonamideAMPA receptorpositive allosteric modulator,[1][2] which is up to 100 times more potent thananiracetamin vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]

See also

[edit]

References

[edit]
  1. ^Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, et al. (April 1998)."Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures".British Journal of Pharmacology.123 (7):1294–303.doi:10.1038/sj.bjp.0701707.PMC 1565288.PMID 9579722.
  2. ^Sekiguchi M, Nishikawa K, Aoki S, Wada K (August 2002)."A desensitization-selective potentiator of AMPA-type glutamate receptors".British Journal of Pharmacology.136 (7):1033–41.doi:10.1038/sj.bjp.0704804.PMC 1573432.PMID 12145103.
  3. ^Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K (August 1997)."A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide".The Journal of Neuroscience.17 (15):5760–71.doi:10.1523/JNEUROSCI.17-15-05760.1997.PMC 6573208.PMID 9221774.
  4. ^Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, et al. (September 2001). "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment".NeuroReport.12 (13):2947–50.doi:10.1097/00001756-200109170-00038.PMID 11588608.S2CID 42785890.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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