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PDE4C

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PDE4C

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2QYM

Identifiers

Aliases

PDE4C, DPDE1, phosphodiesterase 4C, PDE21

External IDs

OMIM:600128;MGI:99556;HomoloGene:20256;GeneCards:PDE4C;OMA:PDE4C - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.11	Start	18,208,652bp^[1]
Band	19p13.11	End	18,248,200bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 B3.3\|8 34.15 cM	Start	71,176,369bp^[2]
Band	8 B3.3\|8 34.15 cM	End	71,203,835bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

muscle of thigh

tibial arteries

spleen

skeletal muscle tissue

gastrocnemius muscle

left ventricle

testicle

muscle layer of sigmoid colon

stromal cell of endometrium

Top expressed in

renal cortex

proximal tubule

human kidney

right kidney

islet of Langerhans

hepatobiliary system

liver

muscle of thigh

muscle tissue

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphoric diester hydrolase activity protein binding 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding 3',5'-cyclic-AMP phosphodiesterase activity
Cellular component	cytosol cell projection extracellular space cilium
Biological process	cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5143


110385

Ensembl


ENSG00000105650


ENSMUSG00000031842

UniProt


Q08493


Q3UEI1

RefSeq (mRNA)

NM_000923 NM_001098818 NM_001098819 NM_001330172 NM_001369701
NM_001395274


NM_201607 NM_001310465

RefSeq (protein)


NP_000914 NP_001092288 NP_001092289 NP_001317101 NP_001356630


NP_001297394 NP_963901

Location (UCSC)

Chr 19: 18.21 – 18.25 Mb

Chr 8: 71.18 – 71.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is anenzyme that in humans is encoded by thePDE4Cgene.^[5]

Tissue localisation

[edit]

PDE4C is predominantly found in peripheraltissues.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000105650 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031842 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
^Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs".Current Pharmaceutical Design.15 (14):1688–1698.doi:10.2174/138161209788168092.PMID 19442182.

Engels P, Sullivan M, Müller T, Lübbert H (1995)."Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)".FEBS Lett.358 (3):305–10.doi:10.1016/0014-5793(94)01460-I.PMID 7843419.S2CID 24276391.
Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse".Somat. Cell Mol. Genet.20 (2):75–86.doi:10.1007/BF02290677.PMID 8009369.S2CID 19182571.
Bolger G, Michaeli T, Martins T, et al. (1993)."A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs".Mol. Cell. Biol.13 (10):6558–71.doi:10.1128/mcb.13.10.6558.PMC 364715.PMID 8413254.
Obernolte R, Ratzliff J, Baecker PA, et al. (1997). "Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis".Biochim. Biophys. Acta.1353 (3):287–97.doi:10.1016/s0167-4781(97)00080-8.PMID 9349724.
Owens RJ, Lumb S, Rees-Milton K, et al. (1998). "Molecular cloning and expression of a human phosphodiesterase 4C".Cell. Signal.9 (8):575–85.doi:10.1016/S0898-6568(97)00072-7.PMID 9429761.
Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND".Cell. Signal.11 (10):735–42.doi:10.1016/S0898-6568(99)00037-6.PMID 10574328.
Zauli G, Milani D, Mirandola P, et al. (2001)."HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway".FASEB J.15 (2):483–91.doi:10.1096/fj.00-0354com.PMID 11156964.S2CID 26315564.
Pérez-Torres S, Miró X, Palacios JM, et al. (2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain".J. Chem. Neuroanat.20 (3–4):349–74.doi:10.1016/S0891-0618(00)00097-1.hdl:10261/112708.PMID 11207431.S2CID 25012736.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays".Science.302 (5653):2141–4.doi:10.1126/science.1090100.PMID 14684825.S2CID 10007258.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004)."The DNA sequence and biology of human chromosome 19".Nature.428 (6982):529–35.Bibcode:2004Natur.428..529G.doi:10.1038/nature02399.PMID 15057824.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:Q08493 (cAMP-specific 3',5'-cyclic phosphodiesterase 4C) at thePDBe-KB.

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Tissue localisation

References

Further reading

External links