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PCTK1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

CDK16

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3MTL

Identifiers

Aliases

CDK16, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1, cyclin-dependent kinase 16, cyclin dependent kinase 16

External IDs

OMIM:311550;MGI:97516;HomoloGene:7878;GeneCards:CDK16;OMA:CDK16 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp11.3	Start	47,217,860bp^[1]
Band	Xp11.3	End	47,229,997bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X A1.3\|X 16.18 cM	Start	20,554,193bp^[2]
Band	X A1.3\|X 16.18 cM	End	20,566,119bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

muscle of thigh

apex of heart

gastrocnemius muscle

right frontal lobe

ganglionic eminence

stromal cell of endometrium

right auricle

prefrontal cortex

ventricular zone

Top expressed in

fossa

condyle

Paneth cell

motor neuron

ascending aorta

aortic valve

substantia nigra

lobe of cerebellum

cerebellar vermis

internal carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein binding protein kinase activity kinase activity ATP binding transferase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity
Cellular component	microtubule cytoskeleton synapse cell junction membrane transport vesicle cytoplasmic vesicle neuron projection extrinsic component of cytoplasmic side of plasma membrane cytoplasm plasma membrane nucleus cytosol synaptic vesicle
Biological process	phosphorylation cell differentiation regulation of insulin secretion involved in cellular response to glucose stimulus protein phosphorylation growth hormone secretion spermatogenesis exocytosis neuron projection development regulation of cell cycle
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5127


18555

Ensembl


ENSG00000102225


ENSMUSG00000031065

UniProt


Q00536


Q04735

RefSeq (mRNA)


NM_001170460 NM_006201 NM_033018 NM_033019


NM_011049 NM_001310456

RefSeq (protein)


NP_001163931 NP_006192 NP_148978


NP_001297385 NP_035179

Location (UCSC)

Chr X: 47.22 – 47.23 Mb

Chr X: 20.55 – 20.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-1 is anenzyme that in humans is encoded by theCDK16gene.^[5]^[6]

Function

[edit]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escapeX inactivation. Two transcript variants encoding the same protein have been found for this gene.^[6]

Interactions

[edit]

PCTK1 has been shown tointeract withCDK5R1.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000102225 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031065 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family".Oncogene.7 (11):2249–58.PMID 1437147.
^^a ^b"Entrez Gene: PCTK1 PCTAIRE protein kinase 1".
^Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002)."Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35".J. Biol. Chem.277 (35):31988–93.doi:10.1074/jbc.M201161200.PMID 12084709.

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992)."A family of human cdc2-related protein kinases".EMBO J.11 (8):2909–17.doi:10.1002/j.1460-2075.1992.tb05360.x.PMC 556772.PMID 1639063.
Knight JC, Renwick PJ, Downing JR, Okuda T (1995). "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3".Cytogenet. Cell Genet.71 (2):155–7.doi:10.1159/000134097.PMID 7656587.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes".Genomics.21 (1):217–21.doi:10.1006/geno.1994.1245.PMID 8088790.
Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, Willard HF (1996)."X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse".Hum. Mol. Genet.5 (3):391–401.doi:10.1093/hmg/5.3.391.PMID 8852665.
Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F (1997). "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins".Mol. Gen. Genet.254 (5):571–7.doi:10.1007/s004380050453.PMID 9197417.S2CID 22809140.
Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R, D'Urso M, Forabosco A (1997). "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E".Genomics.43 (2):183–90.doi:10.1006/geno.1997.4797.PMID 9244435.
Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998)."The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression".J. Biol. Chem.273 (39):25388–92.doi:10.1074/jbc.273.39.25388.PMID 9738006.
Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F (1998)."Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins".Eur. J. Biochem.257 (1):112–20.doi:10.1046/j.1432-1327.1998.2570112.x.PMID 9799109.
Besset V, Rhee K, Wolgemuth DJ (1999). "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation".Cell Growth Differ.10 (3):173–81.PMID 10099831.
Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (2002)."Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35".J. Biol. Chem.277 (35):31988–93.doi:10.1074/jbc.M201161200.PMID 12084709.
Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T (2002)."Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells"(PDF).J. Cell Sci.115 (Pt 17):3479–90.doi:10.1242/jcs.115.17.3479.PMID 12154078.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F (2004)."Protein profile of tax-associated complexes".J. Biol. Chem.279 (1):495–508.doi:10.1074/jbc.M310069200.PMID 14530271.
Palmer KJ, Konkel JE, Stephens DJ (2005)."PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport".J. Cell Sci.118 (Pt 17):3839–47.doi:10.1242/jcs.02496.PMID 16091426.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Liu Y, Cheng K, Gong K, Fu AK, Ip NY (2006)."Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis".J. Biol. Chem.281 (15):9852–8.doi:10.1074/jbc.M513496200.PMID 16461345.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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References

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