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PCPr

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PCPr
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • 1-phenyl-N-propylcyclohexanamine
CAS Number
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC15H23N
Molar mass217.356 g·mol−1
3D model (JSmol)
  • N(CCC)C2(c1ccccc1)CCCCC2
  • InChI=1S/C15H23N/c1-2-13-16-15(11-7-4-8-12-15)14-9-5-3-6-10-14/h3,5-6,9-10,16H,2,4,7-8,11-13H2,1H3 checkY
  • Key:KHXNTQRMMGXPQW-UHFFFAOYSA-N checkY
  (verify)

PCPr is anarylcyclohexylaminedissociativeanesthetic drug withhallucinogenic andstimulant effects. It is around the same potency asphencyclidine, although slightly less potent than the ethyl homologueeticyclidine,[1] and has reportedly been sold as adesigner drug in Germany and other European countries since the late 1990s.[2][3]

Several other related derivatives have also been encountered, with then-propyl group of PCPr replaced by a 2-methoxyethyl, 2-ethoxyethyl or 3-methoxypropyl group to form PCMEA, PCEEA and PCMPA respectively.[4][5][6]

PCMEA, PCEEA and PCMPA

References

[edit]
  1. ^MADDOX VH, GODEFROI EF, PARCELL RF (March 1965). "The Synthesis of Phencyclidine and Other 1-Arylcyclohexylamines".Journal of Medicinal Chemistry.8 (2):230–5.doi:10.1021/jm00326a019.PMID 14332667.
  2. ^Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (April 2008). "Metabolism and toxicological detection of a new designer drug,N-(1-phenylcyclohexyl)propanamine, in rat urine using gas chromatography-mass spectrometry".Journal of Chromatography A.1186 (1–2):380–90.doi:10.1016/j.chroma.2007.11.002.PMID 18035363.
  3. ^Christoph Sauer. Phencyclidine Derivatives – A new Class of Designer Drugs. Studies on the Metabolism and Toxicological Analysis. Universität des Saarlandes, 2008
  4. ^Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (March 2008). "New designer drugsN-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) andN-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques".Journal of Mass Spectrometry.43 (3):305–16.Bibcode:2008JMSp...43..305S.doi:10.1002/jms.1312.PMID 17968862.
  5. ^Sauer C, Peters FT, Schwaninger AE, Meyer MR, Maurer HH (February 2009). "Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugsN-(1-phenyl cyclohexyl)-2-ethoxyethanamine andN-(1-phenylcyclohexyl)-2-methoxyethanamine".Biochemical Pharmacology.77 (3):444–50.doi:10.1016/j.bcp.2008.10.024.PMID 19022226.
  6. ^Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (October 2008). "Metabolism and toxicological detection of the designer drugN-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) in rat urine using gas chromatography-mass spectrometry".Forensic Science International.181 (1–3):47–51.doi:10.1016/j.forsciint.2008.09.001.PMID 18922655.
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