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PCCG-4

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PCCG-4
Identifiers
  • (2S,1'S,2'S,3'R)-2-(2'Carboxy-3'-phenylcyclopropyl)glycine
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC12H13NO4
Molar mass235.239 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N
  • InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1 checkY
  • Key:IFLWVSHRWAIVQF-KATARQTJSA-N checkY
  (verify)

PCCG-4 is a researchdrug which acts as aselectiveantagonist for the group II metabotropic glutamate receptors (mGluR2/3), with slight selectivity for mGluR2 although not sufficient to distinguish mGluR2 and mGluR3 responses from each other. It is used in research into the function of the group II metabotropic glutamate receptors.[1][2][3][4][5]

References

[edit]
  1. ^Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (May 1996). "Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist".Journal of Medicinal Chemistry.39 (11):2259–69.doi:10.1021/jm960059+.PMID 8667369.
  2. ^Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (July 1996). "(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors".Molecular Pharmacology.50 (1):6–9.doi:10.1016/S0026-895X(25)09157-6.PMID 8700119.
  3. ^Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (July 1997). "Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist".The European Journal of Neuroscience.9 (7):1350–5.doi:10.1111/j.1460-9568.1997.tb01489.x.PMID 9240392.S2CID 39993000.
  4. ^Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (September 1999). "Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes".Glia.27 (3):275–81.doi:10.1002/(SICI)1098-1136(199909)27:3<275::AID-GLIA9>3.0.CO;2-0.PMID 10457374.S2CID 42627448.
  5. ^Vetter P, Garthwaite J, Batchelor AM (June 1999). "Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors".Neuropharmacology.38 (6):805–15.doi:10.1016/S0028-3908(99)00003-9.PMID 10465684.S2CID 10116115.
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8


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