| PASTA domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Cartoon representation of PASTA domain from Staphylococcus aureus. PDB entry3m9g | |||||||||||
| Identifiers | |||||||||||
| Symbol | PASTA | ||||||||||
| Pfam | PF03793 | ||||||||||
| InterPro | IPR005543 | ||||||||||
| SMART | PASTA | ||||||||||
| PROSITE | PDOC51178 | ||||||||||
| SCOP2 | 1rp5 /SCOPe /SUPFAM | ||||||||||
| CDD | cd06573 | ||||||||||
| |||||||||||
ThePASTA domain is a smallprotein domain that can bind to thebeta-lactam ring portion of variousβ-lactam antibiotics.[1] The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found inpenicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived fromPBPandSerine/Threonine kinaseAssociated domain.
The PASTA domain adopts a structure composed of analpha-helix followed by threebeta strands. Recent structural studies show that the extracellular region of PknB (protein kinase B) that is composed of four PASTA domains shows a linear arrangement of the domains.[2]
PASTA domains are found in a variety of bacterial species including gram-positiveBacillota andActinomycetota.