 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChemCID | |
| ChemSpider |
|
| UNII | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| Chemical and physical data | |
| Formula | C21H18Br2N2O |
| Molar mass | 474.196 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) (verify) | |
P7C3 (pool 7, compound 3) is adrug related tolatrepirdine (dimebon) which hasneuroprotective andproneurogenic effects and may be potentially useful for the treatment ofAlzheimer's disease and similarneurodegenerative disorders. Thepharmacological effects of P7C3in vitro resemble those ofendogenousproneurogenicpeptides such asfibroblast growth factor 1 (FGF-1), and the proneurogenic activity of P7C3 was around thirty times that oflatrepirdine when they were compared in mice. P7C3 was chosen for further animal studies on the basis of favorablepharmacokinetic factors, such as its highoralbioavailability and longduration of action, but several other related compounds showed similar activity such as the more potent fluorinated analogueP7C3A20 which is up to ten times stronger again, and the methoxy analogueP7C3-OMe, for which it was determined that the (R)enantiomer is the active form.[1]
Themechanism of action of the P7C3 series of compounds involves activation ofnicotinamide phosphoribosyltransferase (NAMPT), therate-limitingenzyme responsible for thetransformation ofnicotinamide intonicotinamide adenine dinucleotide (NAD).[2] By activating NAMPT, the P7C3 compounds result in an increase inintracellular levels of NAD.[2]
 | Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it. |
