The product of this gene, P2Y6, belongs to the family ofG-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive toUDP, partially responsive toUTP andADP, and not responsive toATP. Four transcript variants encoding the same isoform have been identified for this gene.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor".Biochemical and Biophysical Research Communications.222 (2):303–8.doi:10.1006/bbrc.1996.0739.PMID8670200.
Maier R, Glatz A, Mosbacher J, Bilbe G (Aug 1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues".Biochemical and Biophysical Research Communications.237 (2):297–302.doi:10.1006/bbrc.1997.7135.PMID9268704.
Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Aug 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family".Genomics.44 (1):127–30.doi:10.1006/geno.1997.4841.PMID9286708.
Pidlaoan LV, Jin J, Sandhu AK, Athwal RS, Kunapuli SP (Jul 1997). "Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1".Somatic Cell and Molecular Genetics.23 (4):291–6.doi:10.1007/BF02674420.PMID9542531.S2CID24535480.
Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR (Oct 2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1521 (1–3):107–19.doi:10.1016/S0167-4781(01)00291-3.PMID11690642.
Hou M, Harden TK, Kuhn CM, Baldetorp B, Lazarowski E, Pendergast W, Möller S, Edvinsson L, Erlinge D, Schmoldt A, Benthe HF, Haberland G, Klimpel GR, Day KD, Lucas DO, Kalyanaraman VS, Mahadevan S, Kumar SA, Wachter RF, Briggs GP, Pedersen CE, Nozaki M, Bose KS, Sarma RH, Granström G, Linde A (Feb 2002). "UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors".Am J Physiol Heart Circ Physiol.282 (2): H784–92.doi:10.1152/ajpheart.00997.2000.PMID11788430.S2CID19082766.
Cox MA, Gomes B, Palmer K, Du K, Wiekowski M, Wilburn B, Petro M, Chou CC, Desquitado C, Schwarz M, Lunn C, Lundell D, Narula SK, Zavodny PJ, Jenh CH (May 2005). "The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP".Biochemical and Biophysical Research Communications.330 (2):467–73.doi:10.1016/j.bbrc.2005.03.004.PMID15796906.
"P2Y Receptors: P2Y6".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2015-02-17. Retrieved2008-12-09.
