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P2RY4

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

P2RY4

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2B6Q

Identifiers

Aliases

P2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4

External IDs

OMIM:300038;MGI:1926594;HomoloGene:20568;GeneCards:P2RY4;OMA:P2RY4 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq13.1	Start	70,258,166bp^[1]
Band	Xq13.1	End	70,260,204bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X C3	Start	99,633,760bp^[2]
Band	X\|X C3	End	99,638,475bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tibialis anterior muscle

mucosa of ileum

optic nerve

deltoid muscle

skin of abdomen

rectum

skin of limb

skin of leg

skin of hip

transverse colon

Top expressed in

esophagus

right ventricle

tibiofemoral joint

digastric muscle

gastrula

carotid body

liver

jejunum

zone of skin

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity G protein-coupled UTP receptor activity ATP binding G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane apical plasma membrane membrane glutamatergic synapse integral component of presynaptic active zone membrane
Biological process	positive regulation of cytosolic calcium ion concentration phospholipase C-activating G protein-coupled receptor signaling pathway transepithelial chloride transport signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway cellular response to prostaglandin E stimulus G protein-coupled receptor signaling pathway cellular response to ATP regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5030


57385

Ensembl


ENSG00000186912


ENSMUSG00000044359

UniProt


P51582


Q9JJS7

RefSeq (mRNA)


NM_002565


NM_020621

RefSeq (protein)


NP_002556


NP_065646

Location (UCSC)

Chr X: 70.26 – 70.26 Mb

Chr X: 99.63 – 99.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

P2Y purinoceptor 4 is aprotein that in humans is encoded by theP2RY4gene.^[5]^[6]

The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000186912 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000044359 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Communi D, Pirotton S, Parmentier M, Boeynaems JM (Feb 1996)."Cloning and functional expression of a human uridine nucleotide receptor".J Biol Chem.270 (52):30849–52.doi:10.1074/jbc.270.52.30849.PMID 8537336.
^^a ^b"Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4".

External links

[edit]

"P2Y Receptors: P2Y₄".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others