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P2RY1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

P2RY1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

4XNV,4XNW

Identifiers
AliasesP2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDsOMIM:601167;MGI:105049;HomoloGene:1926;GeneCards:P2RY1;OMA:P2RY1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for P2RY1
Genomic location for P2RY1
Band3q25.2Start152,835,131bp[1]
End152,841,439bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for P2RY1
Genomic location for P2RY1
Band3|3 E1Start60,910,216bp[2]
End60,916,403bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • endothelial cell

  • oral cavity

  • internal globus pallidus

  • visceral pleura

  • amniotic fluid

  • placenta

  • nucleus accumbens

  • tibia

  • lower lobe of lung
Top expressed in
  • lumbar spinal ganglion

  • duodenum

  • islet of Langerhans

  • granulocyte

  • jejunum

  • esophagus

  • lip

  • muscle of thigh

  • embryo

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5028

18441

Ensembl

ENSG00000169860

ENSMUSG00000027765

UniProt

P47900

P49650

RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554

NP_001268945
NP_032798

Location (UCSC)Chr 3: 152.84 – 152.84 MbChr 3: 60.91 – 60.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 1 is aprotein that in humans is encoded by theP2RY1gene.[5]

Function

[edit]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000169860Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027765Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor".Biochemical and Biophysical Research Communications.218 (3):783–8.doi:10.1006/bbrc.1996.0139.PMID 8579591.
  6. ^"Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

[edit]

External links

[edit]
  • "P2Y Receptors: P2Y1".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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