P2X purinoceptor 3 is aprotein that in humans is encoded by theP2RX3gene.[5][6]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Garcia-Guzman M, Stühmer W, Soto F (July 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor".Brain Research. Molecular Brain Research.47 (1–2):59–66.doi:10.1016/S0169-328X(97)00036-3.PMID9221902.
Jarvis MF (August 2003). "Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain".Expert Opinion on Therapeutic Targets.7 (4):513–522.doi:10.1517/14728222.7.4.513.PMID12885270.S2CID25459817.
Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A (October 1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons".Nature.377 (6548):432–435.Bibcode:1995Natur.377..432L.doi:10.1038/377432a0.PMID7566120.S2CID4361850.
Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stühmer W (January 1997). "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue".Molecular Pharmacology.51 (1):109–118.doi:10.1124/mol.51.1.109.PMID9016352.
Renton T, Yiangou Y, Baecker PA, Ford AP, Anand P (2003). "Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp".Journal of Orofacial Pain.17 (3):245–250.PMID14520770.
Mason HS, Bourke S, Kemp PJ (December 2004). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species".Molecular Pharmacology.66 (6):1525–1535.doi:10.1124/mol.104.000851.PMID15331767.S2CID24536809.
