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| ECHA InfoCard | 100.004.313 |
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| Formula | C20H28N2O3 |
| Molar mass | 344.455 g·mol−1 |
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Oxyphencyclimine is amuscarinic receptor antagonist, given orally to treatpeptic ulcer disease and gastrointestinalspasms. It hasantispasmodic andantimotility properties.
The reaction ofchloroacetonitrile (1) withmethanol andhydrogen chloride leads to the corresponding iminoether (Pinner reaction). Condensation of2 with 3-methylaminopropylamine gives (3) gives the correspondingtetrahydropyrimidine (4). Displacement of the halogen with the sodium salt5 affords oxyphencyclimine (6).
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