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Oxotremorine

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Oxotremorine
Clinical data

Pregnancy category	C
Routes of administration	Oral, intravenous
ATC code	none
Legal status
Legal status	US: Experimental/not yet approved
Identifiers
IUPAC name 1-(4-Pyrrolidin-1-ylbut-2-yn-1-yl)pyrrolidin-2-one
CAS Number	70-22-4^Y
IUPHAR/BPS	302
ChemSpider	4469^N
UNII	5RY0UWH1JL
ChEMBL	ChEMBL7634^N
CompTox Dashboard(EPA)	DTXSID10220252
ECHA InfoCard	100.000.662
Chemical and physical data
Formula	C₁₂H₁₈N₂O
Molar mass	206.289 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CCN(C1)CC#CCN2CCCC2=O
InChI InChI=InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2^N Key:RSDOPYMFZBJHRL-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Oxotremorine is a drug that acts as a selectivemuscarinic acetylcholine receptor agonist.^[1]

Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.^[2]

Oxotremorine also producesantipsychotic-like effects.^[3]

References

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^Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes".Biochemistry and Molecular Biology International.29 (6):1047–54.PMID 8330013.INIST 4025194.
^Craig CR, Stitzel RE, eds. (2004).Modern Pharmacology with Clinical Applications. Lippincott Williams & Wilkins.ISBN 978-0-7817-3762-3.^{[page needed]}
^Maehara S, Hikichi H, Satow A, Okuda S, Ohta H (November 2008). "Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia".Pharmacology, Biochemistry, and Behavior.91 (1):140–9.doi:10.1016/j.pbb.2008.06.023.PMID 18651995.S2CID 12225821.INIST 20678587.