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Ottaviano de' Medici (14 July 1484 – 28 May 1546) was an Italian politician. He was the ancestor of thePrinces of Ottajano line of theMedici family.

Son of Lorenzo de' Medici and wife Caterina Nerli, he married firstly in 1518 Bartolomea Giugni (Santa Maria del Fiore,Florence, 5 December 1498 - bef. 1533), daughter of Alemanno Giugni and wife, by whom he had two children, Bernadetto de' Medici and Costanza de' Medici (? - 27 March 1606),Governess ofGrand DukeCosimo I de' Medici, married in 1551 to Ugo della Gherardesca (11 December 1530 - 31 December 1589), 1st Count of Donoratico, and had issue.

From a minor branch of the de' Medici family, he gained prominence through his second marriage in 1533 as her second husband to Francesca Salviati (1505 - aft. June 1536), a granddaughter ofLorenzo de' Medici and Ottaviano's own distant cousin.^[1] By this marriage he had two sons, Leone de' Medici, who died young, and Alessandro de' Medici.

He held several important positions inFlorence, including that ofGonfaloniere di Giustizia, although now a merely formal one after the suppression of theRepublic by theSpanishtroops in 1530. He was alsoSenator from 1532.^{[citation needed]} He was trusted byAlessandro de' Medici with administering the family's Tuscan estates.^[2]

His son Alessandro wasCardinal and, from 1605, pope asLeo XI. His other sonBernadetto founded the southern Italian line of the family by acquiring the seigniory ofOttaviano, nearNaples.^[1]

• 1484 births
• 1546 deaths
• House of Medici
• 16th-century Italian nobility
• 16th-century Italian politicians

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