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Osaterone

From Wikipedia, the free encyclopedia
Chemical compound
This article is about a non-clinically used antiandrogen compound. For the pharmaceutical drug, seeosaterone acetate.
Pharmaceutical compound
Osaterone
Clinical data
Other namesTZP-5258; Gestoxarone; 2-Oxachloromadinone; 17α-Hydroxy-6-chloro-2-oxa-6-dehydroprogesterone; 17α-Hydroxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione
ATCvet code
Identifiers
  • (1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-5-chloro-1-hydroxy-9a,11a-dimethyl-2,3,3a,3b,9,9b,10,11-octahydroindeno[4,5-h]isochromen-7-one
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H25ClO4
Molar mass364.87 g·mol−1
3D model (JSmol)
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)OC[C@]34C)Cl)C)O
  • InChI=1S/C20H25ClO4/c1-11(22)20(24)7-5-14-12-8-16(21)15-9-17(23)25-10-18(15,2)13(12)4-6-19(14,20)3/h8-9,12-14,24H,4-7,10H2,1-3H3/t12-,13+,14+,18-,19+,20+/m1/s1
  • Key:ZLLOIFNEEWYATC-XMUHMHRVSA-N

Osaterone (developmental code nameTZP-5258), also known as17α-hydroxy-6-chloro-2-oxa-6-dehydroprogesterone, as well as2-oxachloromadinone, is asteroidalantiandrogen andprogestin that was never marketed.[1][2] The C17αacetateester of osaterone,osaterone acetate, in contrast, has been marketed.[1][2]

References

[edit]
  1. ^abIndex Nominum: International Drug Directory. MedPharm. 2011.ISBN 978-3-8047-5053-1.
  2. ^abMilne GW (8 May 2018).Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. pp. 969–.ISBN 978-1-351-78989-9.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists


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