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Org 28611

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Org 28611
Legal status
Legal status
Identifiers
  • [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3S)-3,4-dimethylpiperazin-1-yl]methanone
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H33N3O2
Molar mass383.536 g·mol−1
3D model (JSmol)
  • COc3cccc(c13)c(C(=O)N(CC2C)CCN2C)cn1CC4CCCCC4
  • InChI=1S/C23H33N3O2/c1-17-14-25(13-12-24(17)2)23(27)20-16-26(15-18-8-5-4-6-9-18)22-19(20)10-7-11-21(22)28-3/h7,10-11,16-18H,4-6,8-9,12-15H2,1-3H3/t17-/m0/s1 checkY
  • Key:ONXJNAIZJKLJGA-KRWDZBQOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Org 28611 (SCH-900,111) is a drug developed byOrganon International which acts as a potentcannabinoidreceptorfull agonist at both theCB1 andCB2 receptors. It was developed with the aim of finding awater-soluble cannabinoid agonist suitable forintravenous use as ananalgesic,[1] and while it achieved this aim and has progressed as far as Phase IIclinical trials in humans as both asedative and ananalgesic, results against the comparison drugs (midazolam andmorphine respectively) were not particularly favourable in initial testing.[2][3]

See also

[edit]

References

[edit]
  1. ^Adam, J. M.; et al. (2010). "Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists".MedChemComm.1.Royal Society of Chemistry: 54.doi:10.1039/c0md00022a.
  2. ^Zuurman L, Passier PC, de Kam M, Kleijn HJ, Cohen AF, van Gerven JM (August 2009). "Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers".Journal of Psychopharmacology.23 (6):633–44.doi:10.1177/0269881108091551.PMID 18635703.S2CID 43609218.
  3. ^A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery
Phytocannabinoids
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