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| Formula | C24H28ClN3O |
| Molar mass | 409.96 g·mol−1 |
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Org 27569 is a drug which acts as a potent and selective negativeallosteric modulator of thecannabinoidCB1receptor. Studiesin vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases thebinding affinity of CB1 agonists such asCP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such asrimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulatingsecond messenger signalling once bound, and so in practice behaves as an insurmountableantagonist of CB1 receptor function.[1]
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