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| Trade names | Pacamine; Neosupranol |
| Other names | Œnethyl; Önethyl; 2-Methylaminoheptane;N,1-Dimethylhexylamine; 2-Heptylmethylamine; 2-(N-Methyl)heptylamine |
| Drug class | Sympathomimetic;Vasopressor;Nasal decongestant |
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| Chemical and physical data | |
| Formula | C8H19N |
| Molar mass | 129.247 g·mol−1 |
| 3D model (JSmol) | |
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Oenethyl, also known as2-methylaminoheptane and sold under the brand namesPacamine andNeosupranol, is asympathomimetic andvasopressormedication of thealkylamine which is no longer marketed.[1][2][3] It was used as anasal decongestant and to controlblood pressure duringanesthesia.[3] It is closelystructurally related to other alkylamines, for instancemethylhexanamine andtuaminoheptane, among others.[3] These compounds are known to act as structurally simplemonoamine releasing agents and to producepsychostimulant-like effects.[4][5][6][2]
With the recent discoveries of N,α-DEPEA, NNDMPPA, methylsynephrine, BMPEA, DMAA, and DMBA as new dietary supplement ingredients the question arises: which stimulant will be next? There are a number of pressor amines that may be selected, such as the pharmaceuticals oenethyl (8) and propylhexedrine (4). In addition, many more variants that can be easily synthesized using the basic structure of the compounds illustrated in Figure 1. [...] Figure 1. Molecular structures of the compounds discussed. [...]
Fig. 1. Molecular structures of aliphatic amines that were used in medicines. [...] Oenethy (Bilhuber) [...] At least 5 different aliphatic amines were eventually marketed as an active ingredient of a medicine: DMAA, tuaminoheptane, octin, oenethyl and propylhexedrine (Table 3) [11]. [...] Table 3. Aliphatic amines with properties similar to DMAA [...] Oenethyl: Initially marketed as a nasal decongestant and also used to control blood pressure during anesthesia [21,22].
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