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Ocedurenone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Ocedurenone
Clinical data
Other namesKBP-5074
Legal status
Legal status
  • Investigational
Identifiers
  • 4-[(3S,3aR)-3-Cyclopentyl-7-(4-hydroxypiperidine-1-carbonyl)-3,3a,4,5-tetrahydropyrazolo[3,4-f]quinolin-2-yl]-2-chlorobenzonitrile
CAS Number
PubChemCID
UNII
Chemical and physical data
FormulaC28H30ClN5O2
Molar mass504.03 g·mol−1

Ocedurenone, formerly known asKBP-5074,[1] is a nonsteroidal, selectivemineralocorticoid receptor antagonist that is being developed to treathypertension in patients withchronic kidney disease with less risk ofhyperkalemia than existing treatments.[2][3] In 2023, KPB Biosciences entered into talks to sell the drug toNovo Nordisk for up to USD$1.3 billion. It is asmall molecule drug administered orally and is in a Phase III trial that is scheduled to complete in 2024.[4][5]

References

[edit]
  1. ^"Ocedurenone: A Novel Therapy for Uncontrolled Hypertension in Advanced Chronic Kidney Disease".Nephrology. 16 March 2023. Retrieved4 November 2023.
  2. ^Pitt, Bertram; Jaisser, Frederic; Bakris, George (October 2021)."An evaluation of KBP-5074 in advanced chronic kidney disease with uncontrolled hypertension".Expert Opinion on Investigational Drugs.30 (10):1017–1023.doi:10.1080/13543784.2021.1985462.ISSN 1744-7658.PMID 34595995.
  3. ^Bakris, George; Pergola, Pablo E.; Delgado, Belkis; Genov, Diyan; Doliashvili, Tamar; Vo, Nam; Yang, Y. Fred; McCabe, James; Benn, Vincent; Pitt, Bertram (July 2021)."Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study".Hypertension.78 (1):74–81.doi:10.1161/HYPERTENSIONAHA.121.17073.PMC 8189259.PMID 33966452.
  4. ^"Novo in $1.3B Deal Buys Late-Stage Hypertension Drug from Singapore Biotech".BioSpace. 16 October 2023. Retrieved4 November 2023.
  5. ^"Novo Nordisk in $1.3 bln deal to buy hypertension drug".Reuters. 16 October 2023. Retrieved4 November 2023.


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