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Solute carrier organic anion transporter family member 1B1

From Wikipedia, the free encyclopedia
(Redirected fromOATP1B1)
Protein found in humans

SLCO1B1
Identifiers
AliasesSLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDsOMIM:604843;MGI:1351899;HomoloGene:74575;GeneCards:SLCO1B1;OMA:SLCO1B1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLCO1B1
Genomic location for SLCO1B1
Band12p12.1Start21,131,194bp[1]
End21,239,796bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for SLCO1B1
Genomic location for SLCO1B1
Band6 G2|6 72.57 cMStart141,575,244bp[2]
End141,632,372bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • testicle

  • buccal mucosa cell

  • pancreatic ductal cell

  • gallbladder

  • renal cortex

  • cervix

  • canal of the cervix

  • mouth

  • haematopoietic system
Top expressed in
  • left lobe of liver

  • embryo

  • sexually immature organism

  • medial head of gastrocnemius muscle

  • primary visual cortex

  • proximal tubule

  • jejunum

  • thoracic diaphragm

  • pancreas

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10599

28253

Ensembl

ENSG00000134538

ENSMUSG00000030236

UniProt

Q9Y6L6

Q9JJL3

RefSeq (mRNA)

NM_006446

NM_020495
NM_178235

RefSeq (protein)

NP_006437

NP_065241

Location (UCSC)Chr 12: 21.13 – 21.24 MbChr 6: 141.58 – 141.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1B1 is aprotein that in humans is encoded by theSLCO1B1gene.[5][6]Pharmacogenomic research indicates that genetic variations in this gene are associated with response tosimvastatin.[7] Clinical guidelines exist that can guide dosing of simvastatin based onSLCO1B1 gene variant usinggenotyping or wholeexomesequencing.[8]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000134538 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000030236 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999)."Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1".J Biol Chem.274 (24):17159–63.doi:10.1074/jbc.274.24.17159.PMID 10358072.
  6. ^"Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1".
  7. ^Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M (2013)."SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink".Clinical Pharmacology & Therapeutics.94 (6):695–701.doi:10.1038/clpt.2013.161.PMC 3831180.PMID 23942138.
  8. ^Huser V, Cimino JJ (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input".AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science.2013: 81.PMID 24303303.

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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