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O-823

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-823
Identifiers
  • 7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]hept-5-ynenitrile
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H27NO2
Molar mass349.474 g·mol−1
3D model (JSmol)
  • Oc2cc(CC#CCCCC#N)cc(OC1(C)C)c2C3C1CC=C(C)C3
  • InChI=1S/C23H27NO2/c1-16-10-11-19-18(13-16)22-20(25)14-17(9-7-5-4-6-8-12-24)15-21(22)26-23(19,2)3/h10,14-15,18-19,25H,4,6,8-9,11,13H2,1-3H3/t18-,19-/m1/s1 checkY
  • Key:MZMMIGOIGWVGEH-RTBURBONSA-N checkY
  (verify)

O-823 is a drug which is acannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoidreceptorCB1, meaning that it acts as an antagonist when co-administered alongside a more potent CB1 agonist, but exhibits weak partial agonist effects when administered by itself.[1][2][3]

References

[edit]
  1. ^Pertwee RG, Fernando SR, Griffin G, Ryan W, Razdan RK, Compton DR, Martin BR (November 1996). "Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations".European Journal of Pharmacology.315 (2):195–201.doi:10.1016/s0014-2999(96)00631-0.PMID 8960884.
  2. ^Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999)."An investigation into the structural determinants of cannabinoid receptor ligand efficacy".British Journal of Pharmacology.126 (7):1575–84.doi:10.1038/sj.bjp.0702469.PMC 1565939.PMID 10323589.
  3. ^Griffin G, Wray EJ, Martin BR, Abood ME (October 1999)."Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum".British Journal of Pharmacology.128 (3):684–8.doi:10.1038/sj.bjp.0702806.PMC 1571656.PMID 10516649.
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