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O-806

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-806
Identifiers
  • (6aR)-3-(6-bromohex-2-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H27BrO2
Molar mass403.360 g·mol−1
3D model (JSmol)
  • C3C1C(CC=C3C)C(C)(C)Oc(c2)c1c(O)cc2CC#CCCCBr
  • InChI=1S/C22H27BrO2/c1-15-9-10-18-17(12-15)21-19(24)13-16(8-6-4-5-7-11-23)14-20(21)25-22(18,2)3/h9,13-14,17-18,24H,5,7-8,10-12H2,1-3H3/t17-,18-/m1/s1 checkY
  • Key:QHFROVGTWNPDOW-QZTJIDSGSA-N checkY
  (verify)

O-806 is a drug which is acannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoidreceptorCB1, meaning that it acts as an antagonist when co-administered alongside a more potent CB1 agonist, but exhibits weak partial agonist effects when administered by itself.[1][2]

References

[edit]
  1. ^Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999)."An investigation into the structural determinants of cannabinoid receptor ligand efficacy".British Journal of Pharmacology.126 (7):1575–84.doi:10.1038/sj.bjp.0702469.PMC 1565939.PMID 10323589.
  2. ^Griffin G, Wray EJ, Martin BR, Abood ME (October 1999)."Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum".British Journal of Pharmacology.128 (3):684–8.doi:10.1038/sj.bjp.0702806.PMC 1571656.PMID 10516649.
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