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O-2694

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-2694
Identifiers
  • (6aR,10aR)-6,6,9-trimethyl-3-(2-methyl-7-morpholin-4-yl-7-oxoheptan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-yl 4-(di(propan-2-yl)amino)butanoate
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC38H60N2O5
Molar mass624.907 g·mol−1
3D model (JSmol)
  • O=C(N1CCOCC1)CCCCC(c3cc2OC([C@@H]4C/C=C(\C[C@H]4c2c(OC(=O)CCCN(C(C)C)C(C)C)c3)C)(C)C)(C)C
  • InChI=1S/C38H60N2O5/c1-26(2)40(27(3)4)18-12-14-35(42)44-32-24-29(37(6,7)17-11-10-13-34(41)39-19-21-43-22-20-39)25-33-36(32)30-23-28(5)15-16-31(30)38(8,9)45-33/h15,24-27,30-31H,10-14,16-23H2,1-9H3/t30-,31-/m1/s1 ☒N
  • Key:OAFUHIZKKMQSAB-FIRIVFDPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

O-2694 is a drug that is acannabinoid derivative. It hasanalgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for bothCB1 andCB2receptors, withKi values of 3.7 nM at CB1 and 2.8 nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of theester link to the water-insoluble compoundO-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compoundO-2545.[1]

See also

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References

[edit]
  1. ^Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, et al. (September 2006). "Pharmacological characterization of novel water-soluble cannabinoids".The Journal of Pharmacology and Experimental Therapeutics.318 (3):1230–9.doi:10.1124/jpet.106.104109.PMID 16757541.S2CID 14864925.
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