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O-2172

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
O-2172
Identifiers
  • methyl 2-cyclopentyl-2-(3,4-dichlorophenyl)acetate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC14H16Cl2O2
Molar mass287.18 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1Cl)C(C(=O)OC)C2CCCC2
  • InChI=1S/C14H16Cl2O2/c1-18-14(17)13(9-4-2-3-5-9)10-6-7-11(15)12(16)8-10/h6-9,13H,2-5H2,1H3 ☒N
  • Key:NEHPFNBRZYFWFN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

O-2172 is a drug developed byOrganix Inc, which acts as astimulant and potentdopamine reuptake inhibitor. It is an analogue ofmethylphenidate where thephenyl ring has had a 3,4-dichloro substitution added, and thepiperidine ring has been replaced bycyclopentane. It is around 1/3 the potency ofmethylphenidate, demonstrating that even with the important binding group of the nitrogen lone pair removed entirely, selectiveDAT binding and reuptake inhibition is still possible.[1][2]

It has been sold as adesigner drug under the nameDCCPM.[3]

See also

[edit]

References

[edit]
  1. ^Meltzer PC, Wang P, Blundell P, Madras BK (April 2003). "Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate".Journal of Medicinal Chemistry.46 (8):1538–1545.doi:10.1021/jm0205292.PMID 12672255.
  2. ^Runyon SP, Carroll FI (2006). "Dopamine transporter ligands: recent developments and therapeutic potential".Current Topics in Medicinal Chemistry.6 (17):1825–1843.doi:10.2174/156802606778249775.PMID 17017960.
  3. ^Yurchenko R, Galetskaya I, Piatsetskaya A (August 2024)."462 O-2172 (DCCPM)".Psychoactive products market observation Annual review. Trend analysis. (56). AIPSIN.doi:10.13140/RG.2.2.21830.28480. RetrievedSeptember 8, 2025.
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DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
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