Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

O-1871

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-1871
Clinical data
ATC code
  • none
Legal status
Legal status
  • Banned as cyclohexylphenol derivative (US, UK)
Identifiers
  • 2-(3,3-dimethylcyclohexyl)-5-(2-methyloctan-2-yl)benzene-1,3-diol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H38O2
Molar mass346.555 g·mol−1
3D model (JSmol)
  • CC(C1)(C)CCCC1C2=C(O)C=C(C(C)(C)CCCCCC)C=C2O
  • InChI=1S/C23H38O2/c1-6-7-8-9-13-23(4,5)18-14-19(24)21(20(25)15-18)17-11-10-12-22(2,3)16-17/h14-15,17,24-25H,6-13,16H2,1-5H3
  • Key:WBSPBIRKSHKQQD-UHFFFAOYSA-N

O-1871 is a potentcannabinoid agonist which was invented by Billy R Martin and Raj K Razdan atOrganix Inc in 2002. It has aCB1 receptor affinity of 2.0 nM and aCB2 receptor affinity of 0.3 nM.[1] Structurally, O-1871 is a cyclohexylphenol derivative related toCP 47,497,[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivativeO-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,[3] which are not cyclohexylphenol derivatives.

O-1656, CAS# 468083-75-2[1]
O-1660,[2]

See also

[edit]

References

[edit]
  1. ^WO application 03091189, Martin BR, Razdan RK, "Cannabinoids", published 6 November 2003, assigned to University of Virginia 
  2. ^Debruyne D, Le Boisselier R (2015)."Emerging drugs of abuse: current perspectives on synthetic cannabinoids".Substance Abuse and Rehabilitation.6:113–29.doi:10.2147/SAR.S73586.PMC 4622447.PMID 26543389.
  3. ^US application 2004087590, Lai XZ, Lu D,Makriyannis A, "Novel biphenyl and biphenyl-like cannabinoids", published 6 May 2004, assigned to University of Connecticut 
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
Cannabiphorols
Cannabinols
Cannabitriols
Cannabivarins
Delta-3-tetrahydrocannabinols
Delta-4-tetrahydrocannabinols
Delta-7-tetrahydrocannabinols
Delta-8-tetrahydrocannabinols
Delta-9-tetrahydrocannabinols
Delta-10-Tetrahydrocannabinols
Delta-11-Tetrahydrocannabinols
Miscellaneous cannabinoids
Active metabolites
Endocannabinoids
Synthetic
cannabinoid
receptor
agonists /
neocannabinoids
Classical cannabinoids
(dibenzopyrans)
Non-classical
cannabinoids
Adamantoylindoles
Benzimidazoles
Benzoylindoles
Cyclohexylphenols
Eicosanoids
Indazole-3-
carboxamides
Indole-3-carboxamides
Indole-3-carboxylates
Naphthoylindazoles
Naphthoylindoles
Naphthoylpyrroles
Naphthylmethylindenes
Naphthylmethylindoles
Phenylacetylindoles
Pyrazolecarboxamides
Tetramethylcyclo-
propanoylindazoles
Tetramethylcyclo-
propanoylindoles
Others
AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers

(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)
Stub icon

Thiscannabinoid related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=O-1871&oldid=1268786683"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp