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Nooglutyl

From Wikipedia, the free encyclopedia
Nooglutyl
Names
IUPAC name
N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid
Systematic IUPAC name
(2S)-2-(5-Hydroxypyridine-3-carboxamido)pentanoic acid
Other names
Nooglutil
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBSA-N
  • InChI=1/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBBD
  • O=C(c1cncc(O)c1)N[C@H](C(=O)O)CCC(=O)O
Properties
C11H12N2O6
Molar mass268.225 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Nooglutyl is anootropic agent that was studied at the Research Institute of Pharmacology,Russian Academy of Medical Sciences as a potential treatment for amnesia.[1]

In animal models, it has a variety ofcentral nervous system effects.[2][3][4][5]

Nooglutyl has some structural similarities topicamilon (N-Nicotinoyl-GABA). Nooglutyl is N-5-HydroxyNicotinoyl-L-Glutamic acid.

See also

[edit]

References

[edit]
  1. ^Flekhter, Oxana B. (2000). "Nooglutil, Russian Academy of Medical Science".Current Opinion in Central & Peripheral Nervous System Investigational Drugs.2 (4):491–497.
  2. ^V. V. Yasnetsov; V. A. Pravdivtsev; V. M. Popov; T. A. Voronina; N. M. Kiseleva; S. B. Kozlov (May 1995). "Antimotion Effect of Nooglutyl and Its Neuronal Mechanism".Bulletin of Experimental Biology and Medicine.119 (5):515–516.doi:10.1007/BF02543440.PMID 7579248.S2CID 6344628.
  3. ^Voronina, TA; Borlikova, GG; Garibova, TL; Proskuryakova, TV; Petrichenko, OB; Burd, SG; Avakyan, GN (2002). "Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum".Bulletin of Experimental Biology and Medicine.134 (5):448–50.doi:10.1023/a:1022634112815.PMID 12802448.S2CID 142803.
  4. ^Garibova, TL; Galaeva, IP; Voronina, TA; Kraĭneva, VA; Kapitsa, IG; Kirichenko, SV; Makarenko, AN; Mirzoian, GR; Kuznetsova, EA (2003). "Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)".Eksperimental'naia i Klinicheskaia Farmakologiia.66 (3):13–6.PMID 12924225.
  5. ^Povarova, OV; Garibova, TL; Kalenikova, EI; Galaeva, IP; Kraĭneva, VA; Medvedev, OS; Voronina, TA (2004). "Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion".Eksperimental'naia i Klinicheskaia Farmakologiia.67 (1):3–6.PMID 15079898.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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