| Nonbacterial thrombotic endocarditis | |
|---|---|
| Specialty | Cardiology  |
| Treatment | Anticoagulation |
Nonbacterial thrombotic endocarditis (NBTE) is a form ofendocarditis in which smallsterilevegetations are deposited on thevalve leaflets. Formerly known asmarantic endocarditis, which comes from theGreekmarantikos, meaning "wasting away".[1] The term "marantic endocarditis" is still sometimes used to emphasize the association with a wasting state[2] such ascancer.[3]
Marantic vegetations are often associated with previousrheumatic fever. Other risk factors include:[citation needed]
The disease affects the valves with following predilection:mitral valve >aortic valve >tricuspid valve >pulmonary valve[4]
Grossly, vegetations form along lines of valve closure and are generally symmetric with a smooth orverrucoid (warty) texture.Histologically, lesions are composed offibrin[5] (eosinophilic) andplatelets but, unlikebacterial etiologies, contain little evidence ofPMNs,microorganisms orinflammation.[citation needed]
Due to the non-invasive nature of NBTE, clinical examination may or may not reveal a newmurmur. An embolic stroke may be the first feature to suggest diagnosis of NBTE. An echocardiogram is essential for visualization of the mass.[citation needed]