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Nomegestrol

From Wikipedia, the free encyclopedia
Chemical compound
This article is about a non-clinically used progestin compound. For the pharmaceutical drug, seenomegestrol acetate.
Pharmaceutical compound
Nomegestrol
Clinical data
Other names19-Normegestrol; 6-Methyl-17α-hydroxy-δ6-19-norprogesterone; 17α-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
ATC code
Identifiers
  • (17α)-17-acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H28O3
Molar mass328.452 g·mol−1
3D model (JSmol)
  • O=C4\C=C3\C(=C/[C@@H]1[C@H](CC[C@@]2([C@@](O)(C(=O)C)CC[C@@H]12)C)[C@H]3CC4)C
  • InChI=1S/C21H28O3/c1-12-10-18-16(15-5-4-14(23)11-17(12)15)6-8-20(3)19(18)7-9-21(20,24)13(2)22/h10-11,15-16,18-19,24H,4-9H2,1-3H3/t15-,16-,18-,19+,20+,21+/m1/s1
  • Key:KZUIYQJTUIACIG-YBZCJVABSA-N

Nomegestrol (INNTooltip International Nonproprietary Name), also known as19-normegestrol, is asteroidalprogestin which was patented in 1975 but was never marketed.[1][2] It is the parent compound ofnomegestrol acetate, which is marketed as a progestin.[1][2]

Nomegestrol shows relatively lowaffinity for theprogesterone receptor, only about 4% of that ofprogesterone and about 1.6% of that ofnomegestrol acetate in oneassay.[3]

See also

[edit]

References

[edit]
  1. ^abJ. Elks (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 883–.ISBN 978-1-4757-2085-3.
  2. ^abIndex Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 747–.ISBN 978-3-88763-075-1.
  3. ^Botella J, Duc I, Delansorne R, Paris J, Lahlou B (December 1990). "Structure-activity and structure-affinity relationships of 19-nor-progesterone derivatives in rat uterus".J. Endocrinol. Invest.13 (11):905–10.doi:10.1007/BF03349652.PMID 2090671.S2CID 37429648.


PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists


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