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| Combination of | |
|---|---|
| Nirmatrelvir | Antiviral drug |
| Ritonavir | CYP3A inhibitor;Antiviral drug |
| Clinical data | |
| Trade names | Paxlovid |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a622005 |
| License data | |
| Pregnancy category | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| KEGG | |
| ChEBI | |
Nirmatrelvir/ritonavir, sold under the brand namePaxlovid, is a co-packagedmedication used as atreatment forCOVID‑19.[7][10][9][17] It contains theantiviral medicationsnirmatrelvir andritonavir and was developed byPfizer.[7][9] Nirmatrelvir inhibitsSARS-CoV-2 main protease, while ritonavir is a strongCYP3A inhibitor, slowing down nirmatrelvirmetabolism and therefore boosting its effect.[9][18] It is takenby mouth.[9]
In unvaccinated high-risk people with COVID‑19, nirmatrelvir/ritonavir can reduce the risk of hospitalization or death by 88% if taken within five days of symptom onset.[19] People who take nirmatrelvir/ritonavir also test negative for COVID‑19 about two and a half days earlier than people who do not.[20]Side effects of nirmatrelvir/ritonavir include changes in sense of taste (dysgeusia),diarrhea, high blood pressure (hypertension), and muscle pain (myalgia).[9]
In December 2021, the United StatesFood and Drug Administration (FDA) granted nirmatrelvir/ritonaviremergency use authorization (EUA) to treat COVID‑19.[12][21] It was approved in the United Kingdom later that month,[22] and in the European Union and Canada in January 2022.[14][23][24] In May 2023, it was approved in the US to treat mild to moderate COVID‑19 in adults who are at high risk for progression to severe COVID‑19, including hospitalization or death.[13][17] The FDA considers the combination to be afirst-in-class medication.[25] In 2023, it was the 159th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[26][27]
In the United States, nirmatrelvir/ritonavir isindicated for the treatment of mild-to-moderate COVID‑19 in adults who are at high risk for progression to severe COVID‑19, including hospitalization or death.[9][13] This includes people above 50, people with diabetes, cancer, coronary artery disease, chronic lung diseases, pregnancy, or on immunosuppressant drugs.[28]
The co-packaged medication is not authorized or suggested for thepre-exposure orpost-exposure prevention of COVID‑19.[11][13][29]
In the European Union, the co-packaged medication is indicated for the treatment of COVID‑19 in adults who do not requiresupplemental oxygen and who are at increased risk for progressing to severe COVID‑19.[14]
If administered within five days of symptom onset in confirmed COVID‑19 infections, theefficacy of the co-packaged medication against hospitalization or death in unvaccinated high-risk adults, as of 2022, was about88% (95%CI,75–94%).[12][19]
The suggestion of the use of co-packaged medication during pregnancy in people who can become pregnant and are not using contraception and for people who are breastfeeding needs further study.[30] Given the risk of morbidity, hospitalization and mortality associated with severe COVID‑19 disease in females and fetuses, nirmatrelvir/ritonavir can provide an important option to reduce the risks associated with acute COVID‑19 infection in at-risk and unvaccinated patients after careful consideration of the benefits and risks for each patient.[30] There is limited human data on the use of nirmatrelvir during pregnancy related to the risk of birth defects, spontaneous abortions (miscarriage), or adverse outcomes.[31] There are no human data on the presence of nirmatrelvir in human milk, or its effects on milk production or the infant.[32] A temporary reduction in body weight was observed in the offspring of nursing rats.[12] Other observational studies have also demonstrated the safety of ritonavir during pregnancy.[33]
The medication is contraindicated in those withhypersensitivity to either of the two main components, and in those with severely reduced kidney or liver function.[12] Co-administration with certain drugs may have serious, sometimes fatal, effects.[34]
Nirmatrelvir/ritonavir has a high potential for potentially seriousdrug interactions due to strongCYP3Ainhibition by ritonavir.[9][18] The US FDA label, the FDA fact sheet, and the FDA EUA contain aboxed warning about the CYP3A inhibition.[9][13]
Adverse events of the co-packaged medication, regardless of causality, observed in thephase II-III EPIC-HR study includeddysgeusia (6% vs. < 1% forplacebo),diarrhea (3% vs. 2% for placebo),hypertension (1% vs. < 1% for placebo), andmyalgia (1% vs. < 1% for placebo).[9][12][35] In clinical trials, 2% of people discontinued treatment due to side effects with nirmatrelvir/ritonavir while 4% in the placebo group did so.[9] Nirmatrelvir/ritonavir is under investigation, so its side effects have yet to be fully evaluated and may not be completely known.[18]
Other side effects of nirmatrelvir/ritonavir may includehypersensitivity reactions,liver toxicity, and development ofHIV drug resistance in people with uncontrolled or undiagnosedHIV infection.[9][18] Hypersensitivity reactions (allergic reactions) may manifest asskin rash,hives,difficulty swallowing,difficulty breathing,angioedema, and/oranaphylaxis.[9][18] Liver toxicity may manifest aselevated transaminases and clinicalhepatitis, including symptoms likeappetite loss,jaundice (yellowing of the skin and whites of eyes),dark-colored urine,pale-colored stools,itchy skin, andabdominal pain.[9][18]
Co-administration of nirmatrelvir/ritonavir with certain drugs is contraindicated, including drugs dependent onCYP3A for removal, for which a raised concentration results in serious reactions, or those with potent CYP3Ainducers, for which reduced blood concentration of the two main components may result in loss of effect against the virus and possible resistance, among others.[9] Co-administration also affects the concentration of several drugs, sometimes requiring changing the dose or careful monitoring.[12][35] Many of these drugs are widely prescribed to people at high risk from COVID‑19.[36] With the extension of the emergency authorization in August 2022, the FDA updated a checklist to help evaluate potential drug interactions and other patient factors before prescribing Paxlovid, including more than 120 drugs that are contraindicated, should be avoided or held from use, or require dose adjustments or special monitoring.[37][12]
Nirmatrelvir/ritonavir is safe to use in combination withover-the-counterpain- andfever-reducing medications such asparacetamol (acetaminophen) andibuprofen.[38]
Nirmatrelvir is responsible for theantiviral activity againstSARS-CoV-2, while ritonavir works by inhibiting themetabolization of nirmatrelvir in the liver, strengthening its activity.[9][18]
Nirmatrelvir is aSARS-CoV-2 main protease (Mpro, 3CLpro, nsp5 protease)inhibitor while ritonavir is anHIV-1 proteaseinhibitor and strongCYP3Ainhibitor.[9][18] Nirmatrelvir is the main active agent in the formulation, while ritonavir, which inhibitsHIV-1 protease, is a strongCYP3A inhibitor: it inhibits the metabolization of nirmatrelvir in the liver and thereby strengthens or boosts its activity.[9][18] Ritonavir is not active against or thought to directly contribute to the medication's antiviral activity against SARS-CoV-2.[18][9] Nirmatrelvir/ritonavir works against COVID‑19 by preventing thereplication of SARS-CoV-2, which the SARS-CoV-2 main protease is essential for.[9][18]
Thetime to peak concentrations of nirmatrelvir combined with ritonavir is 3.00 hours (range 1.02–6.00 hours), while that of ritonavir is 3.98 hours.[9]Peak concentrations of nirmatrelvir combined with ritonavir following a single dose (300 mg nirmatrelvir and 100 mg ritonavir) in healthy individuals are 2.21 μg/mL whiletotal exposure is 23.01 μg•h/mL.[9] Taking nirmatrelvir/ritonavir with a high-fat meal modestly increases exposure to nirmatrelvir (peak concentrations increased by 15% and total exposure increased by 1.6%) relative to taking them under fasting conditions.[9]
Thevolume of distribution (Vz/F) of nirmatrelvir combined with ritonavir is 104.7 L while that of ritonavir is 112.4 L.[9] Theblood-to-plasma ratio of nirmatrelvir combined with ritonavir is 0.60 while thered-blood-cell-to-plasma ratio of ritonavir is 0.14.[9] Theplasma protein binding of nirmatrelvir combined with ritonavir is 69% while that of ritonavir is 98 to 99%.[9]
Nirmatrelvir is mainly asubstrate ofCYP3A in terms of itsmetabolism.[9] But when it is combined with ritonavir, a strong CYP3A4 inhibitor, nirmatrelvir's metabolism is minimal and itselimination instead is mainly viarenalexcretion.[9] Ritonavir is eliminated mainly byhepatic metabolism, withCYP3A4 the majorenzyme involved andCYP2D6 the minor enzyme.[9]
Nirmatrelvir combined with ritonavir is excreted 35.3% infeces and 49.6% inurine, while ritonavir is excreted 86.4% in feces and 11.3% in urine.[9]
Theoral clearance (CL/F) of nirmatrelvir combined with ritonavir is 8.99 while that of ritonavir is 13.92.[9] Theelimination half-life of nirmatrelvir combined with ritonavir is (mean ± SD) 6.05 ± 1.79 hours while that of ritonavir is 6.15 hours.[9] The half-life of nirmatrelvir combined with ritonavir makes the formulation suitable for administration every 12 hours.[9][18]
The pharmacokinetics of nirmatrelvir/ritonavir based on age or gender have not been assessed.[9] Exposure to nirmatrelvir/ritonavir was numerically lower in Japanese than in Western people, but not to a clinically meaningful extent.[9] Peak concentrations, total exposure, time to peak concentrations, and elimination half-life of nirmatrelvir combined with ritonavir are severity-dependently increased in people withrenal impairment,[9] but not increased in people with moderatehepatic impairment.[9] The combination has not been studied in people with severe hepatic impairment.[9]
Research suggests that nirmatrelvir/ritonavir may minimize the risk oflong COVID.[28] A 2025 recent report indicates that Paxlovid may benefit certainlong COVID patients, though it remains unclear which individuals are most likely to respond.[39] A study examined 13 long COVID patients who underwent extended treatment with theantiviral drug.[40] The results were mixed: nine patients experienced some improvement, but only five reported lasting effects, while four saw no improvement.[40] The findings highlight the ongoing uncertainty surrounding effective treatments for long COVID, nearly five years into the pandemic, more properly pandemia. Although some patients recover naturally or respond to various therapies, no universally effective treatment has been identified.
An additional analysis of the original EPIC-HR clinical trial data (Delta variant) showed that about 2% of both the treatment and placebo groups experienced asymptomatic rebound after the five-day treatment, meaning they felt ill again and tested positive again (antigen test and PCR test) after testing negative.[41] The exact cause is not known, but there is speculation that it is due to reservoirs in tissues that are not reached by the medication, or reinfection. In May 2022, Pfizer suggested repeating the treatment, but the FDA said there was no evidence of benefit.[42][43]
In June 2022, a US case report of ten people with rebound COVID‑19 had found viral load during relapse was comparable to levels during an initial infection, and high enough to cause secondary transmission.[44] PresidentJoe Biden, First LadyJill Biden,Anthony Fauci,[42]Peter Hotez, andRochelle Walensky[45] are known to have experienced rebound. As of June 2022, Pfizer studied the phenomenon in a new trial it called EPIC-SR (standard risk) while theomicron variant was circulating.[44] Both EPIC-HR and EPIC-SR were randomized controlled trials that provide information about COVID‑19 rebound.[13] Data from these trials showed that rebound in SARS-CoV-2 (RNA or virus) shedding or COVID‑19 symptoms occurred in a subset of participants and happened in both the participants receiving nirmatrelvir/ritonavir and the placebo.[13] As of 2023, the FDA found there was no clear association between nirmatrelvir/ritonavir treatment and COVID‑19 rebound based on data available to them.[13]
As of July 2022, no nirmatrelvir/ritonavirdrug resistant SARS-CoV-2 had been observed in clinical context.[46] The engineering of a nirmatrelvir-resistant chimera ofvesicular stomatitis virus (VSV) under laboratory conditions was published without formal peer review in July 2022.[47] As of November 2022, multiple pathways that could lead to resistance to nirmatrelvir/ritonavir had been demonstratedin vitro.[48]
Nirmatrelvir belongs to a family of3C-likeprotease inhibitors developed in the late 2010s againstfeline coronavirus, while ritonavir is anantiretroviral drug developed in the 1980s and used since the 1990s to inhibit the enzyme that metabolizes other protease inhibitors.
The primary data supporting the USFood and Drug Administration (FDA)emergency use authorization for nirmatrelvir/ritonavir were from the EPIC-HR trial, a randomized, double-blind, placebo-controlled clinical trial studying nirmatrelvir/ritonavir for the treatment of non-hospitalized symptomatic adults with a laboratory-confirmed diagnosis of SARS-CoV-2 infection.[9][11][49] Participants were 18 years of age and older with a pre-specified risk factor for progression to severe disease, or were 60 years and older regardless of pre-specified chronic medical conditions.[11] No participants had received a COVID‑19 vaccine or been previously infected with COVID‑19.[11] The main outcome measured in the trial was the proportion of people who were hospitalized due to COVID‑19 or died due to any cause during 28 days of follow-up.[11] EPIC-HR started in July 2021, and completed in December 2021.[50] Nirmatrelvir/ritonavir significantly reduced the proportion of people with COVID‑19-related hospitalization or death from any cause by 88% compared to placebo among participants treated within five days of symptom onset and who did not receive COVID‑19 therapeutic monoclonal antibody treatment.[11] In December 2021, Pfizer also announced that a Phase II/III study of nirmatrelvir/ritonavir showed a reduced risk of hospitalization or death.[51]
In August 2021, Pfizer began aphase II/III trial of nirmatrelvir/ritonavir for COVID‑19 in standard-risk individuals with COVID‑19 known as EPIC-SR.[52][53] Interim results of this trial were announced in December 2021, and final results were released in June 2022.[52] Pfizer discontinued enrollment in the study, with the reason given being the very low rate of hospitalization and death in this population.[54] EPIC-SR was another clinical trial that enrolled vaccinated participants with at least one risk factor for progression to severe COVID‑19.[13] Although not statistically significant, among these vaccinated participants, there was a reduction in the risk of COVID‑19 related hospitalization or death from any cause.[13]
In December 2021, nirmatrelvir/ritonavir was grantedemergency use authorization by the United StatesFood and Drug Administration (FDA) for the treatment of COVID‑19.[12] In December 2021, the United Kingdom'sMedicines and Healthcare products Regulatory Agency (MHRA) approved the use of nirmatrelvir combined with ritonavir for adults with mild to moderate infection and at high risk of their illness worsening.[55][22]
In April 2022, it was announced that thePANORAMIC trial would start testing the effectiveness of nirmatrelvir/ritonavir for treating COVID‑19 infections.[56]
Nirmatrelvir/ritonavir has been evaluated in the treatment of COVID‑19 in standard-risk individuals in the EPIC-SR trial.[52][54] This study did not achieve its primary goal of reducing time to sustained alleviation of COVID‑19 symptoms (treatment: 13 days (95% CI 12–15 days); placebo: 13 days (95% CI 11–14 days)).[52][54] It also did not find a statistically significant reduction in the risk of hospitalization or death (treatment: 5/576 [0.9%]; placebo: 10/569 [1.8%]; p > 0.05).[52][54] Likewise, findings were not statistically significant for reducing hospitalization rates in a subgroup of vaccinated adults with at least one risk factor for severe COVID‑19 (treatment: 3/361 [0.8%]; placebo: 7/360 [1.9%]; 57% reduction – RR 0.43, 95% CI 0.11–1.64).[52][54] However, the trial did find a statistically significant 62% decrease in COVID‑19-related medical visits, similar to the 67% reduction from the EPIC-HR study of high-risk individuals.[52][54] Enrollment in EPIC-SR was discontinued due to the low rate of hospitalization and death in this population.[52][54]
In May 2023, nirmatrelvir/ritonavir received FDA approval for the treatment of mild-to-moderate COVID‑19 in adults who are at high risk for progression to severe COVID‑19, including hospitalization or death.[13] In November 2023, the FDA revised the EUA for nirmatrelvir/ritonavir to authorize EUA- or NDA-labeled nirmatrelvir/ritonavir for the treatment of mild-to-moderate COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb), who are at high risk for progression to severe COVID‑19, including hospitalization.[17] In March 2024, the FDA revised the EUA for nirmatrelvir/ritonavir to remove the authorization for EUA-labeled nirmatrelvir/ritonavir.[57][17]
Health Canada approved the use of the co-packaged medication in January 2022.[6][23][58][59][60]
In February 2022, China approved the medication for the treatment of adults who have mild to moderate COVID‑19 and are at a high risk of progressing to a severe condition.[61]
TheEuropean Medicines Agency (EMA) approved the co-packaged medication for the treatment of COVID‑19 in the EU in January 2022.[14][15]
TheIsraeli Ministry of Health approved the use of the co-packaged medication in December 2021.[62]
The JapaneseMinistry of Health, Labour and Welfare approved the use of the co-packaged medication for treating adults in February 2022.[63]
The SingaporeHealth Sciences Authority approved the use of the co-packaged medication for treating adults in February 2022.[64]
South Korea approved the use of the co-packaged medication in December 2021.[65]
The United Kingdom approved the use of the co-packaged medication in December 2021.[7][8][66]
In November 2021, Pfizer submitted an application to the USFood and Drug Administration (FDA) foremergency use authorization for the co-packaged medication.[67][68][69] The authorization was granted in December 2021, for people aged twelve years of age or older who are infected with COVID‑19 and are at risk.[11][17][70]
In January 2024, the FDA revised the emergency use authorization (EUA) and stated that nirmatrelvir/ritonavir manufactured and labeled in accordance with the EUA under US distribution would remain authorized for use through the earlier of the labeled or extended expiration date, or through March 2024.[57] In March 2024, the FDA revised the emergency use authorization to no longer cover EUA-labeled nirmatrelvir/ritonavir.[17][57] As of November 2024, the FDA emergency use authorization for nirmatrelvir/ritonavir continues to authorize it for the treatment of people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who are at high risk for progression to severe COVID-19, including hospitalization or death.[12][57][17][71] The emergency use authorization also continues to authorize prescribing of nirmatrelvir/ritonavir by a state-licensed pharmacist to treat mild to moderate COVID-19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who are at high risk for progression to severe COVID-19, including hospitalization or death, in accordance with the FDA-approved prescribing information or authorized labeling, as applicable, and subject to certain conditions as detailed in the letter of authorization and the authorized fact sheet for health care providers.[12][17][57][72]
Pfizer selected its largest oraltablet factory inFreiburg as the launch facility for manufacturing the co-packaged medication.[73] Nirmatrelvir, the novel portion of the co-packaged medication, was developed in the US and was initially manufactured in small amounts inGroton, Connecticut, to support clinical trials,[74] but the Freiburg facility was responsible for figuring out how to mass-produce the co-packaged medication on an industrial scale.[73] Pfizer selected another factory inAscoli Piceno, Italy, to assist the Freiburg factory with packaging tablets intoblister packs.[75]
In December 2021, the German government ordered one million doses, but by August 2022, wholesalers had delivered only around 43,000 to pharmacies. In Germany, nirmatrelvir/ritonavir has been by prescription through physicians only, and German physicians have been reluctant to prescribe it. Hence, health ministerKarl Lauterbach decided that general practitioners could stock five nirmatrelvir/ritonavir courses in their practice and dispense it directly to patients, that a prescription would be remunerated with 15 euros, and that every nursing home should appoint a vaccination officer as well as a nirmatrelvir/ritonavir officer. As of August 2022 the treatment guidelines German family doctors follow had not been updated since February 2022 and recommended nirmatrelvir/ritonavir only in unvaccinated risk patients, i.e., only a few people.[76]
As of April 2022, the US had ordered 20 million nirmatrelvir/ritonavir courses.[77] As of July 2022, theUnited States Department of Health and Human Services had set up at least 2,200 sites where people could receive nirmatrelvir/ritonavir as soon as they tested positive for the virus, including pharmacies, community health centers and long-term care facilities.[70] In July 2022, the FDA allowed state-licensed pharmacists to prescribe it to people with COVID‑19 at high risk of progressing to severe disease.[78]
Throughout 2022, only 10-12% of eligible US adult outpatients had received nirmatrelvir/ritonavir.[28] Reasons are suspected to be concerns about "rebound, unfamiliarity with the treatment and cost" as well as "confusion around who's at high risk for severe disease".[28] Paxlovid treatment was free through the end of 2024, for Medicare and Medicaid beneficiaries and insured persons covering out-of-pocket costs.[28][79] Paxlovid continues to be free for some Medicare and Medicaid beneficiaries through the end of 2025, via the US Government Patient Assistance Program.[80]
Pfizer reported revenue ofUS$1.279 billion for Paxlovid in 2023.[81]
Nirmatrelvir/ritonavir is sold under the brand name Paxlovid.[9] Primovir and Paxista are generic versions manufactured and distributed in India.[82][83]
In 2021, it was falsely claimed that nirmatrelvir/ritonavir is a repackaged version of theantiparasitic drugivermectin, or that nirmatrelvir/ritonavir is just like ivermectin as both are protease inhibitors.[84][85] Ivermectin has been falsely[86] promoted as a COVID‑19 therapeutic. Such claims, sometimes using the nickname "Pfizermectin",[87] arise from superficial similarities between the mechanism of action of the drugs[84] and the claim that Pfizer is suppressing information about the benefits of ivermectin.[85]
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