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Niperotidine

From Wikipedia, the free encyclopedia
Niperotidine
Names
Preferred IUPAC name
(Z)-N1-[(2H-1,3-Benzodioxol-5-yl)methyl]-N′1-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-2-nitroethene-1,1-diamine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard100.076.612Edit this at Wikidata
EC Number
  • 284-304-0
KEGG
MeSHC073716
UNII
  • InChI=1S/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3 ☒N
    Key: VZPXHGJTEAPNAA-UHFFFAOYSA-N ☒N
  • InChI=1/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3
    Key: VZPXHGJTEAPNAA-UHFFFAOYAQ
  • CN(C)Cc1ccc(o1)CSCCN/C(=C\[N+](=O)[O-])NCc2cc3OCOc3cc2
Properties
C20H26N4O5S
Molar mass434.51 g·mol−1
Pharmacology
A02BA05 (WHO)
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound

Niperotidine is ahistamine antagonist selective for theH2 subtype. It was studied as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showedliver damage.[2]

References

[edit]
  1. ^Palasciano, G; Maggi, V; Portincasa, P (1990). "The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring".The Italian Journal of Gastroenterology.22 (5):291–4.PMID 1983712.
  2. ^Gasbarrini, G; Gentiloni, N; Febbraro, S; Gasbarrini, A; Di Campli, C; Cesana, M; Miglio, F; Miglioli, M; Ghinelli, F; d'Ambrosi, A; Amoroso, P; Pacini, F; Salvadori, G (1997). "Acute liver injury related to the use of niperotidine".Journal of Hepatology.27 (3):583–6.doi:10.1016/s0168-8278(97)80365-0.PMID 9314138.
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists


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