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| Other names | Roniacol; Roniacol tartrate; Nicotinyl tartrate;[1] Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol |
| AHFS/Drugs.com | Monograph |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.002.604 |
| Chemical and physical data | |
| Formula | C6H7NO |
| Molar mass | 109.128 g·mol−1 |
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Nicotinyl alcohol (pyridylcarbinol) is aniacin derivative used as ahypolipidemic agent and as avasodilator. It causes flushing and may decrease blood pressure.[2]
It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.[citation needed]
Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, likearteriosclerosis obliterans,[3]Raynaud's disease,[4] thromboangiitis obliterans (Buerger's disease),[5] arterial embolism,chilblains or migraine associated with vascular spasm.
Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related tointermittent claudication,[6] ulcer healing and others.[7]
At least a couple of uses for this agent were discovered over the years: