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Neuropeptide Y receptor Y1

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

NPY1R

Available structures

Ortholog search:PDBe RCSB

List of PDB id codes
2F1U,2IIL

Identifiers

NPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1

External IDs

OMIM:162641;MGI:104963;HomoloGene:700;GeneCards:NPY1R;OMA:NPY1R - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q32.2	Start	163,323,962bp^[1]
Band	4q32.2	End	163,344,832bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 B3.1\|8 33.15 cM	Start	67,149,844bp^[2]
Band	8 B3.1\|8 33.15 cM	End	67,159,444bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

spleen

popliteal artery

tibial arteries

right adrenal cortex

left adrenal cortex

Descending thoracic aorta

adipose tissue

germinal epithelium

superficial temporal artery

subcutaneous adipose tissue

Top expressed in

ascending aorta

aortic valve

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

primary visual cortex

trigeminal ganglion

muscle of thigh

hippocampus proper

posterior horn of spinal cord

spinal ganglia

More reference expression data


More reference expression data

Gene ontology
Molecular function	neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity protein binding peptide YY receptor activity pancreatic polypeptide receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway locomotory behavior regulation of multicellular organism growth G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger outflow tract morphogenesis blood circulation regulation of blood pressure feeding behavior glucose metabolic process sensory perception of pain neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Species

Human

Mouse


4886


18166


ENSG00000164128


ENSMUSG00000036437


P25929


Q04573

RefSeq (mRNA)


NM_000909


NM_010934 NM_001358955

RefSeq (protein)


NP_000900


NP_035064 NP_001345884

Location (UCSC)

Chr 4: 163.32 – 163.34 Mb

Chr 8: 67.15 – 67.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Neuropeptide Y receptor type 1 is aprotein that in humans is encoded by theNPY1Rgene.^[5]^[6]

Selective ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
Peptide YY

Antagonists

Peptide

BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

BIBO-3304 (CAS# 191868-14-1)
BIBP-3226 (CAS# 159013-54-4)
PD-160,170 (CAS# 181468-88-2)

Available Structures

5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)^[7]
5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)^[7]

See also

Neuropeptide Y receptor

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164128 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000036437 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993)."Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor".The Journal of Biological Chemistry.268 (9):6703–7.doi:10.1016/S0021-9258(18)53306-8.PMID 8095935.
^"Entrez Gene: NPY1R neuropeptide Y receptor Y1".
^^a ^bYang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018)."1 receptor".Nature.556 (7702):520–524.doi:10.1038/s41586-018-0046-x.PMC 5920736.PMID 29670288.

Further reading

Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes".Life Sciences.56 (13):1055–64.doi:10.1016/0024-3205(95)00041-4.PMID 9001438.
Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status".European Journal of Pharmacology.440 (2–3):173–87.doi:10.1016/S0014-2999(02)01427-9.PMID 12007534.
Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y".Biopolymers.60 (6):420–37.doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W.PMID 12209475.
Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992)."Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type".The Journal of Biological Chemistry.267 (16):10935–8.doi:10.1016/S0021-9258(19)49854-2.PMID 1317848.
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992)."Cloned human neuropeptide Y receptor couples to two different second messenger systems".Proceedings of the National Academy of Sciences of the United States of America.89 (13):5794–8.Bibcode:1992PNAS...89.5794H.doi:10.1073/pnas.89.13.5794.PMC 402104.PMID 1321422.
Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995)."Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor".The Journal of Biological Chemistry.270 (39):22661–4.doi:10.1074/jbc.270.39.22661.PMID 7559383.
Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002)."Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor".The Journal of Biological Chemistry.277 (8):6645–55.doi:10.1074/jbc.M107224200.PMID 11741903.
Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]".Peptides.23 (1):87–96.doi:10.1016/S0196-9781(01)00583-6.PMID 11814622.S2CID 54419749.
Cox HM, Tough IR (March 2002)."Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa".British Journal of Pharmacology.135 (6):1505–12.doi:10.1038/sj.bjp.0704604.PMC 1573267.PMID 11906964.
Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues".Peptides.23 (5):927–34.doi:10.1016/S0196-9781(02)00003-7.PMID 12084524.S2CID 31244551.
Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina".Glia.39 (3):320–4.doi:10.1002/glia.10107.PMID 12203398.S2CID 41750584.
Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction".The Journal of Pharmacology and Experimental Therapeutics.306 (1):147–56.doi:10.1124/jpet.103.051227.PMID 12665544.S2CID 40163065.
Lehner B, Sanderson CM (July 2004)."A protein interaction framework for human mRNA degradation".Genome Research.14 (7):1315–23.doi:10.1101/gr.2122004.PMC 442147.PMID 15231747.
Körner M, Waser B, Reubi JC (December 2004)."High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia".Clinical Cancer Research.10 (24):8426–33.doi:10.1158/1078-0432.CCR-04-0821.PMID 15623622.

External links

"Neuropeptide Y Receptors: Y₁".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.
Overview of all the structural information available in thePDB forUniProt:P25929 (Neuropeptide Y receptor type 1) at thePDBe-KB.

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Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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