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Neuromedin U receptor 2

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

NMUR2

Identifiers

NMUR2, FM-4, FM4, NMU-R2, NMU2R, TGR-1, TGR1, Neuromedin U receptor 2

External IDs

OMIM:605108;MGI:2441765;HomoloGene:49618;GeneCards:NMUR2;OMA:NMUR2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q33.1	Start	152,391,546bp^[1]
Band	5q33.1	End	152,433,368bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B1.3	Start	55,915,813bp^[2]
Band	11\|11 B1.3	End	55,931,836bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibialis anterior muscle

testicle

mucosa of ileum

deltoid muscle

corpus callosum

skin of thigh

C1 segment

internal globus pallidus

right testis

right lung

Top expressed in

embryo

submandibular gland

cervix

jejunum

duodenum

skin of abdomen

trachea

stomach

More reference expression data

n/a

Gene ontology
Molecular function	protein binding signal transducer activity neuromedin U binding neuropeptide receptor activity neuromedin U receptor activity intracellular calcium activated chloride channel activity GTP binding G protein-coupled receptor activity
Cellular component	integral component of membrane membrane plasma membrane intracellular anatomical structure
Biological process	reduction of food intake in response to dietary excess calcium ion transport phospholipase C-activating G protein-coupled receptor signaling pathway activation of phospholipase A2 activity feeding behavior inositol phosphate-mediated signaling regulation of smooth muscle contraction arachidonic acid secretion positive regulation of cytosolic calcium ion concentration cell-cell signaling response to pain calcium-mediated signaling signal transduction grooming behavior central nervous system development G protein-coupled receptor signaling pathway neuropeptide signaling pathway ion transmembrane transport regulation of sensory perception of pain
Sources:Amigo /QuickGO

Species

Human

Mouse


56923


216749


ENSG00000132911


ENSMUSG00000037393


Q9GZQ4


Q8BZ39

RefSeq (mRNA)


NM_020167


NM_153079

RefSeq (protein)


NP_064552


NP_694719

Location (UCSC)

Chr 5: 152.39 – 152.43 Mb

Chr 11: 55.92 – 55.93 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Neuromedin-U receptor 2 is aprotein that in humans is encoded by theNMUR2gene.^[5]^[6]^[7]

Ligands

Agonists

synephrine^[8]

See also

Neuromedin U receptor

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000132911 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000037393 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors".Trends Biotechnol.14 (11):426–30.doi:10.1016/0167-7799(96)10059-7.PMID 8940772.
^Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding".Nature.406 (6791):70–4.doi:10.1038/35017610.PMID 10894543.S2CID 205007370.
^"Entrez Gene: NMUR2 neuromedin U receptor 2".
^Zheng X, Guo L, Wang D, Deng X (2014)."p-Synephrine: a novel agonist for neuromedin U2 receptor".Biol Pharm Bull.37 (5):764–70.doi:10.1248/bpb.b13-00788.PMID 24598981.

Further reading

Hosoya M, Moriya T, Kawamata Y, et al. (2000)."Identification and functional characterization of a novel subtype of neuromedin U receptor".J. Biol. Chem.275 (38):29528–32.doi:10.1074/jbc.M004261200.PMID 10887190.
Raddatz R, Wilson AE, Artymyshyn R, et al. (2000)."Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system".J. Biol. Chem.275 (42):32452–9.doi:10.1074/jbc.M004613200.PMID 10899166.
Shan L, Qiao X, Crona JH, et al. (2001)."Identification of a novel neuromedin U receptor subtype expressed in the central nervous system".J. Biol. Chem.275 (50):39482–6.doi:10.1074/jbc.C000522200.PMID 11010960.
Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin".Peptides.23 (9):1617–23.doi:10.1016/S0196-9781(02)00099-2.hdl:10651/41212.PMID 12217422.S2CID 9986371.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Bhattacharyya S, Luan J, Farooqi IS, et al. (2004)."Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor".J. Endocrinol.183 (1):115–20.doi:10.1677/joe.1.05830.PMID 15525579.
Mori K, Miyazato M, Ida T, et al. (2005)."Identification of neuromedin S and its possible role in the mammalian circadian oscillator system".EMBO J.24 (2):325–35.doi:10.1038/sj.emboj.7600526.PMC 545815.PMID 15635449.
Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones".Neurosci. Lett.404 (1–2):148–53.doi:10.1016/j.neulet.2006.05.034.PMID 16781063.S2CID 26500367.

External links

"Neuromedin U Receptors: NMU2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-05.

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Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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