Natriuresis is the process ofsodium excretion in theurine through the action of thekidneys.^[1] It is promoted byventricular andatrial natriuretic peptides as well ascalcitonin,^[2] and inhibited by chemicals such asaldosterone. Natriuresis lowers theconcentration of sodium in the blood and also tends to lower blood volume becauseosmotic forces drag water out of the body'sblood circulation and into the urine along with the sodium. Manydiureticdrugs take advantage of this mechanism to treat medical conditions likehypernatremia andhypertension, which involve excess blood volume.

Excess natriuresis can be caused by:

• Medullary cystic disease
• Bartter syndrome
• Diuretic phase ofacute tubular necrosis
• Somediuretics
• Primaryrenal diseases
• Congenital adrenal hyperplasia
• Syndrome of inappropriate antidiuretic hormone hypersecretion

Endogenous natriuretic hormones include:

• Atrial natriuretic peptide
• Brain natriuretic peptide
• C-type natriuretic peptide^[3]

This is a natural process in infants at the time of birth.

Further reading

• Granger, JP; Alexander, BT; Llinas, M (2002). "Mechanisms of pressure natriuresis".Current Hypertension Reports.4 (2):152–9.doi:10.1007/s11906-002-0040-3.PMID 11884271.S2CID 46323264.
• Hall, J. E.; Mizelle, H. L.; Hildebrandt, D. A.; Brands, M. W. (1990)."Abnormal pressure natriuresis. A cause or a consequence of hypertension?".Hypertension.15 (6_Pt_1):547–59.doi:10.1161/01.HYP.15.6.547.PMID 1971810.

• Renal physiology

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