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 Aerial photo of the NIH Mark O. Hatfield Clinical Research Center, Bethesda, Maryland | |
| Agency overview | |
|---|---|
| Formed | 1953 (1953) |
| Jurisdiction | United States |
| Headquarters | Bethesda,Maryland, U.S. 39°0′6″N77°6′16″W / 39.00167°N 77.10444°W /39.00167; -77.10444 |
| Agency executive |
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| Parent agency | National Institutes of Health,Department of Health & Human Services |
| Website | www |
TheNIH Clinical Center is a hospital solely dedicated toclinical research at theNational Institutes of Health campus inBethesda, Maryland. The Clinical Center, known as Building 10, consists of the original part of the hospital, theWarren Grant Magnuson Clinical Center, and the newest addition, theMark O. Hatfield Clinical Research Center. The two parts are connected to form one large building.[1]
Since the hospital's opening in 1953,[2] NIH scientists have worked with volunteer patients to create medical innovations. Clinical Center successes include pioneering the cure of cancerous solid tumors withchemotherapy; the use ofnitroglycerin to treat heart attacks; identifying a genetic component inschizophrenia; conducting the first successful replacement of amitral valve to treatheart disease; and the creation of blood tests to identify bothAcquired Immune Deficiency Syndrome (AIDS) andhepatitis.[3]
In October 2014, Clinical Center staff successfully treated one of the first fewEbola virus cases in the United States.
The Clinical Center has been a leader in the “bench-to-bedside” concept. Its specialized hospital design places patient care units in close proximity to research laboratories. This model supports interaction andcollaboration among clinical researchers.
The Clinical Center also provides training opportunities for students, new and mid-career professionals.[4] A SummerInternship Program offers internships to students who are currently enrolled in high school, college, graduate programs and health professional schools such asnursing ormedicine.[5] The Medical Research Scholars Program is a year-long research enrichment program designed for research-oriented medical,dental andveterinary students.[6] The Clinical Research ManagementSabbatical is a self-directed educational experience designed for clinical research investigators and managers of clinical research programs.[7] The Clinical Center also provides a course called the Introduction to the Principles and Practice of Clinical Research to trainphysicians,scientists, medical students, nurses and other health professionals how to effectively conduct clinical research.[8]
The Warren Grant Magnuson Clinical Center opened in 1953 and is 13 floors at its highest point. It is named after SenatorWarren Magnuson ofWashington.
The Mark O. Hatfield Clinical Research Center, located at the north end of the Clinical Center, opened in 2005. It was named after SenatorMark Hatfield ofOregon.[9]
The hospital has 200 inpatient beds, 11 operating rooms, 93day hospital stations, critical care services and research labs, anambulatory care research facility and a complex array of imaging services. The Clinical Center is also one of the few facilities in the world with state-of-the-art infrastructure that allows forisolation capabilities andinfection control while patients participate in clinical research studies.[1][10]
Patients at the Clinical Center consent to participate in research studies, also called protocols, and are treated without charge. Admission is selective: only those patients who have a medical condition being studied by NIH Institutes or Centers and who meet the specific inclusion criteria can enroll in the studies.
In 2014, there were 1,611 clinical research studies underway at the Clinical Center including those focused oncancer,infectious diseases,blood disorders,heart disease,lung disease,alcoholism anddrug abuse.[1]
More than 500,000 patients from all 50 states, and from countries around the world, have participated in clinical research at the Clinical Center.[1]
John I. Gallin served as director of the Clinical Center beginning in May 1994. In January 2017, as part of an update to the hospital's leadership structure, NIH directorFrancis S. Collins namedJames K. Gilman to the newly created position of chief executive officer Clinical Center. With the arrival of Gilman, Gallin assumed new roles as the NIH Associate Director for Clinical Research and Chief Scientific Officer, Clinical Center.[11]
Past directors 1948–present[12]
| No. | Portrait | Director | Took office | Left office | Refs |
|---|---|---|---|---|---|
| 1 |  | Jack Masur | 1948 | 1951 | |
| 2 |  | John A. Trautman | July 1, 1951 | June 24, 1954 | [13] |
| 3 |  | Donald W. Patrick | 1954 | 1956 | [14] |
| 4 | | Jack Masur | November 1, 1956 | March 8, 1969 | [15][16] |
| 5 |  | Thomas C. Chalmers | February 9, 1970 | 1973 | [17][18] |
| 6 | .jpg) | Robert S. Gordon, Jr. | January 7, 1974 | September 1975 | [19] |
| acting | Roger L. Black | September 1975 | March 1976 | [20] | |
| acting | Griff Ross | April 1976 | 1976 | [21][22] | |
| 7 |  | Mortimer B. Lipsett | 1976 | 1982 | [23] |
| 8 |  | John L. Decker | August 1, 1983 | May 31, 1990 | [24][25] |
| acting |  | Saul Rosen | June 1, 1990 | April 30, 1994 | [26] |
| 9 |  | John I. Gallin | May 1, 1994 | January 8, 2017 | [27] |
| 10 |  | James K. Gilman | January 9, 2017 | January 31, 2025 | [28][29] |
| acting |  | Pius Aiyelawo | March 24, 2025 | present | [30] |
In 2014, the NIH Clinical Center had 1,611 active research protocols. 48% of those wereclinical trials (773 protocols), another 46% werenatural history studies (744 protocols) and the remaining 6% were screening and training protocols.[31]
The Clinical Center provides an environment for bothpatient care and conducting clinical trials, most of which are inPhase I orPhase II.[1] In 2014, of the 773 active clinical trials protocols, 23% were Phase I trials (261 protocols), 60% were Phase II trials (462 protocols), 5% werePhase III (39 protocols) and 3% werePhase IV (11 protocols).[31]
The Clinical Center also integrates data from all intramural clinical trials in an integrated data repository called Biomedical Translational Research Information System (BTRIS).[32]
TheDiscovery Channel documentaryFirst In Human: The Trials of Building 10, hosted byJim Parsons, aired in August 2017.[33] The three-episode documentary showed experiences of some staff, patients and caregivers at the NIH Clinical Center.
It is not exceptional for a hospital to have a [hospital-originating] infection ... They occur in every hospital.
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