At age 14, Henstridge entered the Casablanca Modeling Agency's Look of the Year contest and was chosen first runner-up. The following year, she went toParis to pursue her modeling ambitions. At age 15, she was featured on her first magazine cover, the French edition ofCosmopolitan. Several more magazine covers followed and Henstridge went on to do television commercials for products such asOlay,Old Spice, and Lady Stetson. With her modeling career established, Henstridge started doing commercials and decided she preferred acting. One of her first roles was as Foxy Fox in the Missoula Children's Theater production ofSnow White and the seven Dwarfs staged in Fort McMurray.[5]
In her film debutSpecies (1995), Henstridge played Sil, a genetically engineered alien/human hybrid created from a message received bySETI, who breaks free from the captivity of a laboratory. Pursued by a team of experts who band together to stop her, she embarks on a killing spree while also discovering her powerful instinct to mate, which would result in her offspring being a threat to mankind.[5]Species was an instant hit, making US$113 million at thebox office.[6] Notable for its sexual content, the film won Henstridge theMTV Movie Award for Best Kiss for a scene in which her character, while kissing an abusive date, impales his head with her tongue. In 1998, she played Eve, a more ambiguous genetic duplicate of Sil, inSpecies II, which was a failure at the box office. BetweenSpecies films, Henstridge starred in two action films in 1996,Adrenalin: Fear the Rush withChristopher Lambert andMaximum Risk oppositeJean-Claude Van Damme.[5]
A few smaller independent movies followed, includingBela Donna andDog Park, with varied box-office returns. Henstridge starred in the filmThe Whole Nine Yards (2000) and its sequelThe Whole Ten Yards (2004). Despite having some reservations about the science-fiction genre, she signed up forJohn Carpenter'sGhosts of Mars (2001) in the lead role of Lieutenant Melanie Ballard. The film was not well received, with a 20% rating onRotten Tomatoes.[7] In 2004, she briefly appeared as Eve inSpecies III.
Henstridge has played a number of roles on television, for example inCaracara andThe Outer Limits. From 2005 to 2006, she had a recurring role as the speaker's chief of staff on the ABC dramaCommander in Chief, which starredGeena Davis as a fictional female U.S. president. She also hostedMostly True Stories: Urban Legends Revealed onTLC, a show abouturban legends. She guest-starred as a substitute teacher in the first-seasonSouth Park episode "Tom's Rhinoplasty", and was credited as "the chick fromSpecies".
In 2008, Henstridge played a role on the ABC comedy-drama seriesEli Stone. She has also been involved with two other productions, joining the cast of Dave Rodriguez'sAnytown, an indie drama that examines a racist high-school attack and its aftermath. She has also been involved with the production ofShould've Been Romeo from American Independent Pictures.
In 2009, Henstridge did a guest spot onThe Tonight Show withConan O'Brien. During this, she demonstrated a Newfoundland custom called "screeching in", which involved getting O'Brien to drinkNewfoundland Screech rum and kiss a large fish.[11]
In 2011, she appeared on the season-9 finale and season-10 premiere ofCSI: Miami as Renee Locklear. She then starred in theCW television seriesThe Secret Circle as Dawn Chamberlain.
Henstridge married American actorDamian Chapa in 1995; they divorced in 1996.
She dated American actor Liam Waite from 1996 to 2004; they have two sons together.[12]
She began a relationship with Scottish singerDarius Campbell in 2004.[13] They became engaged, but broke it off in early 2010,[14] then married onValentine's Day 2011. They filed for divorce in July 2013. The divorce was finalized in February 2018.[15]
In June 2009, Henstridge spoke of her past use of diet pills in combination with extreme diets for weight loss; she said this damaged her metabolism and led to subsequent weight gain.[16]
In November 2017, during the height of the#MeToo movement, Henstridge joined six other actresses in accusing directorBrett Ratner of sexual assault and harassment; she maintains that he forced her to performoral sex on him in the early 1990s.[17] She also accused producerHarvey Weinstein of sexual harassment.[18]