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Naminidil

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Naminidil
Clinical data
Other namesBMS-234303; BMS234303
Routes of
administration
Topical[1]
Drug classATP-sensitivepotassium channel opener;Vasodilator
ATC code
  • None
Identifiers
  • 1-cyano-3-(4-cyanophenyl)-2-[(2R)-3,3-dimethylbutan-2-yl]guanidine
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC15H19N5
Molar mass269.352 g·mol−1
3D model (JSmol)
  • C[C@H](C(C)(C)C)N=C(NC#N)NC1=CC=C(C=C1)C#N
  • InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)/t11-/m1/s1
  • Key:PGYDRGZVXVVZQC-LLVKDONJSA-N

Naminidil (INNTooltip International Nonproprietary Name,USANTooltip United States Adopted Name; developmental code nameBMS-234303) is anATP-sensitivepotassium channel opener withvasodilator activity which was under development as atopical medication for the treatment ofandrogenic alopecia (pattern hair loss) but was never marketed.[2][3][1] The drug was under development byBristol-Myers Squibb and reachedphase 2clinical trials by 2001.[2] One of the phase 2 trials compared naminidil, minoxidil, andplacebo for alopecia.[1] However, no results of the study appear to have been made available.[1] Development of naminidil was discontinued by 2008.[2] In terms ofchemical structure, naminidil is aguanidinederivative and is structurally distinct fromminoxidil.[2][4]

See also

[edit]

References

[edit]
  1. ^abcdPoulos GA, Mirmirani P (February 2005). "Investigational medications in the treatment of alopecia".Expert Opinion on Investigational Drugs.14 (2):177–184.doi:10.1517/13543784.14.2.177.PMID 15757393.
  2. ^abcd"Naminidil".AdisInsight. 17 January 2008. Retrieved23 July 2025.
  3. ^"Delving into the Latest Updates on Naminidil with Synapse".Synapse. 20 July 2025. Retrieved23 July 2025.
  4. ^"Naminidil".PubChem. U.S. National Library of Medicine. Retrieved24 July 2025.


Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels


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