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NUAK2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

NUAK2

Identifiers

Aliases

NUAK2, SNARK, NUAK family kinase 2, ANPH2

External IDs

OMIM:608131;MGI:1921387;HomoloGene:12539;GeneCards:NUAK2;OMA:NUAK2 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	205,302,063bp^[1]
Band	1q32.1	End	205,321,745bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E4	Start	132,243,864bp^[2]
Band	1\|1 E4	End	132,261,226bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

blood

mucosa of ileum

gingival epithelium

mucosa of pharynx

granulocyte

epithelium of esophagus

palpebral conjunctiva

renal medulla

mucosa of transverse colon

kidney tubule

Top expressed in

right kidney

jejunum

granulocyte

proximal tubule

human kidney

mesenteric lymph nodes

ileum

epithelium of lens

colon

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein binding protein kinase activity metal ion binding kinase activity transferase activity protein serine/threonine kinase activity ATP binding magnesium ion binding
Cellular component	cytoplasm nucleus
Biological process	phosphorylation apoptotic process actin cytoskeleton organization negative regulation of apoptotic process intracellular signal transduction protein phosphorylation cellular response to glucose starvation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


81788


74137

Ensembl


ENSG00000163545


ENSMUSG00000009772

UniProt


Q9H093


Q8BZN4

RefSeq (mRNA)


NM_030952


NM_001195025 NM_028778

RefSeq (protein)


NP_112214


NP_001181954 NP_083054

Location (UCSC)

Chr 1: 205.3 – 205.32 Mb

Chr 1: 132.24 – 132.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

NUAK family SNF1-like kinase 2 also known asSNF1/AMP kinase-related kinase (SNARK) is anenzyme that in humans is encoded by theNUAK2gene.^[5]^[6] Its deficiency in humans causesanencephaly, a severe form of anteriorneural tube defect that curtails brain development.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000163545 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000009772 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001)."Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs".Genome Res.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
^"Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2".
^Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, et al. (December 2020)."A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling".The Journal of Experimental Medicine.217 (12) e20191561.doi:10.1084/jem.20191561.PMC 7953732.PMID 32845958.

Hartley JL, Temple GF, Brasch MA (2001)."DNA cloning using in vitro site-specific recombination".Genome Res.10 (11):1788–95.doi:10.1101/gr.143000.PMC 310948.PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1 (3):287–92.doi:10.1093/embo-reports/kvd058.PMC 1083732.PMID 11256614.
Lefebvre DL, Bai Y, Shahmolky N, et al. (2001)."Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK".Biochem. J.355 (Pt 2):297–305.doi:10.1042/0264-6021:3550297.PMC 1221739.PMID 11284715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family".Biochem. Biophys. Res. Commun.311 (1):156–61.doi:10.1016/j.bbrc.2003.09.184.PMID 14575707.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Lizcano JM, Göransson O, Toth R, et al. (2005)."LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1".EMBO J.23 (4):833–43.doi:10.1038/sj.emboj.7600110.PMC 381014.PMID 14976552.
Legembre P, Schickel R, Barnhart BC, Peter ME (2004)."Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness".J. Biol. Chem.279 (45):46742–7.doi:10.1074/jbc.M404334200.PMID 15345718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004)."From ORFeome to biology: a functional genomics pipeline".Genome Res.14 (10B):2136–44.doi:10.1101/gr.2576704.PMC 528930.PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307 (5715):1621–5.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID 15761153.S2CID 39457788.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34 (Database issue): D415–8.doi:10.1093/nar/gkj139.PMC 1347501.PMID 16381901.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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