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NS102

From Wikipedia, the free encyclopedia
NS102[1]
Names
IUPAC name
5-Nitro-6,7,8,9-tetrahydro-1H-benzo[g]indole-2,3-dione 3-oxime
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C12H11N3O4/c16-12-11(14-17)8-5-4-6-7(10(8)13-12)2-1-3-9(6)15(18)19/h4-5,9,17H,1-3H2,(H,13,14,16) ☒N
    Key: FQJXCCSUWTUFRG-UHFFFAOYSA-N ☒N
  • InChI=1/C12H11N3O4/c16-12-11(14-17)8-5-4-6-7(10(8)13-12)2-1-3-9(6)15(18)19/h4-5,9,17H,1-3H2,(H,13,14,16)
    Key: FQJXCCSUWTUFRG-UHFFFAOYAV
  • O=C2NC1=C3C(CCCC3)=C([N+]([O-])=O)C=C1/C2=N/O
Properties
C12H11N3O4
Molar mass261.237 g·mol−1
AppearanceYellow solid
Insoluble
Solubility in DMSO>3 mg/mL
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

NS102 is akainate receptorantagonist.[2][3]

References

[edit]
  1. ^NS102 atSigma-Aldrich
  2. ^Johansen, Tina H; Drejer, Joergen; Watjen, Frank; Nielsen, Elsebet O (1993). "A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding".European Journal of Pharmacology.246 (3):195–204.doi:10.1016/0922-4106(93)90031-4.PMID 8223944.
  3. ^Dev KK, Petersen V, Honoré T, Henley JM (1996). "Pharmacology and regional distribution of the binding of 6-[3H]nitro-7-sulphamoylbenzo[f]-quinoxaline-2,3-dione to rat brain".J. Neurochem.67 (6):2609–12.doi:10.1046/j.1471-4159.1996.67062609.x.PMID 8931496.S2CID 39382212.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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