Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known asNPR3, is anatrial natriuretic peptide receptor. In humans it is encoded by theNPR3gene.[5]
The family ofnatriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[5]
Pitzalis MV, Sarzani R, Dessì-Fulgheri P, et al. (2003). "Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype".J. Hypertens.21 (8):1491–6.doi:10.1097/00004872-200308000-00012.hdl:11566/50999.PMID12872042.S2CID40988095.
Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize".Mol. Pharmacol.67 (1):174–83.doi:10.1124/mol.104.002436.PMID15459247.S2CID53520.
He XL, Dukkipati A, Garcia KC (2006). "Structural determinants of natriuretic peptide receptor specificity and degeneracy".J. Mol. Biol.361 (4):698–714.doi:10.1016/j.jmb.2006.06.060.PMID16870210.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment".Am. J. Med. Genet. B Neuropsychiatr. Genet.150B (6):808–16.doi:10.1002/ajmg.b.30902.PMID19086053.S2CID44524739.
van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors".J. Mol. Biol.311 (5):923–37.doi:10.1006/jmbi.2001.4922.PMID11556325.
He XL, Dukkipati A, Wang X, Garcia KC (2005). "A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C".Peptides.26 (6):1035–43.doi:10.1016/j.peptides.2004.08.035.PMID15911071.S2CID28281513.
