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NPR2

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From Wikipedia, the free encyclopedia

Human protein-coding gene

NPR2

Identifiers

Aliases

NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B

External IDs

OMIM:108961;MGI:97372;HomoloGene:2970;GeneCards:NPR2;OMA:NPR2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p13.3	Start	35,791,003bp^[1]
Band	9p13.3	End	35,809,732bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 A5\|4 23.05 cM	Start	43,631,935bp^[2]
Band	4 A5\|4 23.05 cM	End	43,651,244bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

right hemisphere of cerebellum

anterior pituitary

canal of the cervix

ascending aorta

Descending thoracic aorta

body of uterus

stromal cell of endometrium

left uterine tube

muscle layer of sigmoid colon

Top expressed in

neural layer of retina

soleus muscle

ankle

skin of external ear

extraocular muscle

muscle of thigh

median eminence

cumulus cell

spinal ganglia

tunica media of zone of aorta

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein kinase activity nucleotide binding hormone binding GTP binding lyase activity identical protein binding phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity natriuretic peptide receptor activity peptide hormone binding protein binding adenylate cyclase activity peptide receptor activity
Cellular component	integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble integral component of plasma membrane intracellular anatomical structure
Biological process	negative regulation of meiotic cell cycle regulation of cardiac conduction intracellular signal transduction ossification negative regulation of oocyte maturation cyclic nucleotide biosynthetic process regulation of blood pressure cGMP biosynthetic process protein phosphorylation cellular response to granulocyte macrophage colony-stimulating factor stimulus bone development receptor guanylyl cyclase signaling pathway reproductive process positive regulation of cGMP-mediated signaling cGMP-mediated signaling signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


4882


230103

Ensembl


ENSG00000159899


ENSMUSG00000028469

UniProt


P20594


Q6VVW5

RefSeq (mRNA)


NM_000907 NM_003995 NM_001378923


NM_173788 NM_001355466

RefSeq (protein)


NP_003986 NP_001365852


NP_776149 NP_001342395

Location (UCSC)

Chr 9: 35.79 – 35.81 Mb

Chr 4: 43.63 – 43.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Natriuretic peptide receptor B (NPR2), also known asatrionatriuretic peptide receptor B and formerly asguanylate cyclase B, is anatrial natriuretic peptide receptor which in humans is encoded by theNPR2gene.^[5]

Amutation in theNPR2 gene can result inachondroplasia anddisproportionate dwarfism with short limbs.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000159899 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000028469 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".
^Tsuji T, Kunieda T (April 2005)."A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse".The Journal of Biological Chemistry.280 (14):14288–92.doi:10.1074/jbc.C500024200.PMID 15722353.

External links

[edit]

NPR2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Neuropeptide receptors

G protein-coupled receptor

Hormone receptors

Hypothalamic	CRH FSH LHRH TRH Somatostatin
Pituitary	Vasopressin 1A 1B 2 Oxytocin LHCG TSH
Other	Atrial natriuretic factor NPR3 Calcitonin Cholecystokinin A B VIP

Opioid receptors

Other neuropeptide receptors

Type I cytokine receptor

Enzyme-linked receptor

Atrial natriuretic factor
- NPR1
- NPR2

Other

Sigma
- 1
- 2

Cell surface receptors:enzyme-linked receptors

Receptor protein serine/threonine kinase

Receptor tyrosine kinase

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR PDGFRA PDGFRB
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3 VEGFR4
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3
EPH receptor family	EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB5 EPHB6 EPHX
LTK receptor family	LTK ALK
TIE receptor family	TIE TEK
ROR receptor family	ROR1 ROR2
DDR receptor family	DDR1 DDR2
PTK7 receptor family	PTK7
RYK receptor family	RYK
MuSK receptor family	MUSK
ROS receptor family	ROS1
AATYK receptor family	AATYK AATYK2 AATYK3
AXL receptor family	AXL MER TYRO3
RET receptor family	RET
uncategorised	STYK1

Guanylate cyclase-coupled receptor

ANP:NPR1
NPR2

Receptor tyrosine phosphatase

Phosphorus–oxygenlyases (EC 4.6)

4.6.1

Adenylate cyclase
(4.6.1.1)

intracellular	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10
extracellular	Extracellular adenylate cyclase

Guanylate cyclase
(4.6.1.2)

soluble guanylyl cyclase	GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3
guanylate cyclase-coupled receptor	GUCY2C GUCY2D ANP (NPR1 NPR2)

Other

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)