Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known asNPR1, is anatrial natriuretic peptide receptor. In humans it is encoded by theNPR1gene.
NPR1 is a membrane-boundguanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP andBNP, respectively).[5]
It is localized in the kidney[6] where it results innatriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs andadipocytes.[6]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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