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NFIA

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
For the airport in Niagara Falls, New York, seeNiagara Falls International Airport.
NFIA
Identifiers
AliasesNFIA, CTF, NF-I/A, NF1-A, NFI-A, NFI-L, nuclear factor I A, BRMUTD
External IDsOMIM:600727;MGI:108056;HomoloGene:4086;GeneCards:NFIA;OMA:NFIA - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for NFIA
Genomic location for NFIA
Band1p31.3Start60,865,259bp[1]
End61,462,788bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for NFIA
Genomic location for NFIA
Band4 C5- C6|4 45.52 cMStart97,660,971bp[2]
End98,007,111bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • urethra

  • saphenous vein

  • vena cava

  • buccal mucosa cell

  • cardia

  • nipple

  • parietal pleura

  • endothelial cell

  • synovial joint
Top expressed in
  • seminal vesicula

  • vestibular membrane of cochlear duct

  • vestibular sensory epithelium

  • external carotid artery

  • Rostral migratory stream

  • internal carotid artery

  • lobe of cerebellum

  • cerebellar vermis

  • atrioventricular valve

  • facial motor nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4774

18027

Ensembl

ENSG00000162599

ENSMUSG00000028565

UniProt

Q12857

Q02780

RefSeq (mRNA)

NM_001134673
NM_001145511
NM_001145512
NM_005595

NM_001122952
NM_001122953
NM_010905

RefSeq (protein)

NP_001128145
NP_001138983
NP_001138984
NP_005586

NP_001116424
NP_001116425
NP_035035

Location (UCSC)Chr 1: 60.87 – 61.46 MbChr 4: 97.66 – 98.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor 1 A-type is aprotein that inhumans isencoded by theNFIAgene.[5][6]

Function

[edit]

Nuclear factor I (NFI) proteins constitute a family of dimericDNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellulartranscription factors and as replication factors foradenovirusDNA replication. Diversity in this protein family is generated by multiplegenes, differentialsplicing, and heterodimerization.[supplied by OMIM][6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000162599Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028565Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Qian F, Kruse U, Lichter P, Sippel AE (July 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH".Genomics.28 (1):66–73.doi:10.1006/geno.1995.1107.PMID 7590749.
  6. ^ab"Entrez Gene: NFIA nuclear factor I/A".

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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