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NFE2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NFE2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2KZ5

Identifiers
AliasesNFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDsOMIM:601490;MGI:97308;HomoloGene:4491;GeneCards:NFE2;OMA:NFE2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NFE2
Genomic location for NFE2
Band12q13.13Start54,292,111bp[1]
End54,301,015bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for NFE2
Genomic location for NFE2
Band15 F3|15 58.62 cMStart103,156,639bp[2]
End103,166,830bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • monocyte

  • granulocyte

  • trabecular bone

  • bone marrow

  • bone marrow cells

  • spleen

  • testicle

  • right lung

  • upper lobe of left lung
Top expressed in
  • granulocyte

  • fetal liver hematopoietic progenitor cell

  • tibiofemoral joint

  • blood

  • spleen

  • human fetus

  • yolk sac

  • embryo

  • bone marrow

  • body of femur
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4778

18022

Ensembl

ENSG00000123405

ENSMUSG00000058794

UniProt

Q16621

Q07279

RefSeq (mRNA)
NM_001136023
NM_001261461
NM_006163
NM_001400365
NM_001400372

NM_001400373

NM_008685
NM_001302338
NM_001302339
NM_001302340
NM_001302341

NM_001302343
NM_001400376

RefSeq (protein)

NP_001129495
NP_001248390
NP_006154

NP_001289267
NP_001289268
NP_001289269
NP_001289270
NP_001289272

NP_032711
NP_001387305

Location (UCSC)Chr 12: 54.29 – 54.3 MbChr 15: 103.16 – 103.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor NF-E2 45 kDa subunit is aprotein that in humans is encoded by theNFE2gene.[5][6]

It is involved inmegakaryocyte production.[7]

Interactions

[edit]

NFE2 has been shown tointeract withCREB-binding protein.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000123405Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000058794Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993)."Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner".Mol Cell Biol.13 (9):5604–12.doi:10.1128/mcb.13.9.5604.PMC 360284.PMID 8355703.
  6. ^"Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
  7. ^Gasiorek JJ, Blank V (2015)."Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells".Cellular and Molecular Life Sciences.72 (12):2323–2335.doi:10.1007/s00018-015-1866-6.PMC 11114048.PMID 25721735.S2CID 18020988.
  8. ^Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001)."Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation".J. Biol. Chem.276 (14):10715–21.doi:10.1074/jbc.M007846200.PMID 11154691.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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