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Neurogenin-1

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From Wikipedia, the free encyclopedia

(Redirected fromNEUROG1)

Protein-coding gene

NEUROG1

Identifiers

Aliases

NEUROG1, AKA, Math4C, NEUROD3, bHLHa6, ngn1, neurogenin 1

External IDs

OMIM:601726;MGI:107754;HomoloGene:4490;GeneCards:NEUROG1;OMA:NEUROG1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q31.1	Start	135,534,282bp^[1]
Band	5q31.1	End	135,535,964bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 B1\|13 30.06 cM	Start	56,398,291bp^[2]
Band	13 B1\|13 30.06 cM	End	56,399,976bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

right ovary

Top expressed in

ventricular zone

urethra

female urethra

male urethra

rhombic lip

hair

trigeminal ganglion

Jacobson's organ

embryo

pretectal area

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding protein dimerization activity DNA-binding transcription factor activity chromatin binding protein binding protein homodimerization activity E-box binding sequence-specific double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	perikaryon soma nucleus
Biological process	regulation of neuron differentiation neurogenesis cell differentiation cell fate commitment regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of exit from mitosis transcription, DNA-templated nervous system development multicellular organism development positive regulation of neuron differentiation neuron differentiation positive regulation of transcription by RNA polymerase II thorax and anterior abdomen determination trigeminal nerve development vestibulocochlear nerve formation peristalsis auditory behavior genitalia morphogenesis inner ear morphogenesis regulation of muscle organ development genitalia development inner ear development neuromuscular process controlling balance mastication cochlea development cochlea morphogenesis craniofacial suture morphogenesis learned vocalization behavior negative regulation of relaxation of muscle negative regulation of saliva secretion hard palate morphogenesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


4762


18014

Ensembl


ENSG00000181965


ENSMUSG00000048904

UniProt


Q92886


P70660

RefSeq (mRNA)


NM_006161


NM_010896

RefSeq (protein)


NP_006152


NP_035026

Location (UCSC)

Chr 5: 135.53 – 135.54 Mb

Chr 13: 56.4 – 56.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neurogenin-1 is aprotein that in humans is encoded by theNEUROG1gene.^[5]^[6]

Interactions

[edit]

NEUROG1 has been shown tointeract withCREB-binding protein^[7] anddecapentaplegic homolog 1.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000181965 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000048904 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively".Genomics.40 (2):355–7.doi:10.1006/geno.1996.4578.PMID 9119405.
^"Entrez Gene: NEUROG1 neurogenin 1".
^^a ^bSun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001)."Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms".Cell.104 (3):365–76.doi:10.1016/S0092-8674(01)00224-0.PMID 11239394.S2CID 1534352.

McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996)."NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family".Molecular and Cellular Biology.16 (10):5792–800.doi:10.1128/mcb.16.10.5792.PMC 231580.PMID 8816493.
Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001)."Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms".Cell.104 (3):365–76.doi:10.1016/S0092-8674(01)00224-0.PMID 11239394.S2CID 1534352.
Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain".Journal of Child Neurology.16 (11):849–53.doi:10.1177/08830738010160111201.PMID 11732772.S2CID 20069074.
Kim S, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim H (Dec 2002)."Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells".Experimental & Molecular Medicine.34 (6):469–75.doi:10.1038/emm.2002.65.PMID 12526089.
Fanous AH, Chen X, Wang X, Amdur RL, O'Neill FA, Walsh D, Kendler KS (Mar 2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia".American Journal of Medical Genetics Part B.144B (2):207–14.doi:10.1002/ajmg.b.30423.PMID 17044100.S2CID 24638656.
Liscovitch N, Chechik G (2013)."Specialization of gene expression during mouse brain development".PLOS Computational Biology.9 (9) e1003185.Bibcode:2013PLSCB...9E3185L.doi:10.1371/journal.pcbi.1003185.PMC 3777910.PMID 24068900.

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