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NEUROD1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

NEUROD1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2QL2

Identifiers
AliasesNEUROD1, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D
External IDsOMIM:601724;MGI:1339708;HomoloGene:1871;GeneCards:NEUROD1;OMA:NEUROD1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NEUROD1
Genomic location for NEUROD1
Band2q31.3Start181,668,295bp[1]
End181,680,827bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for NEUROD1
Genomic location for NEUROD1
Band2 C3|2 47.58 cMStart79,282,865bp[2]
End79,287,095bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • paraflocculus of cerebellum

  • cerebellar vermis

  • right hemisphere of cerebellum

  • islet of Langerhans

  • ganglionic eminence

  • pons

  • testicle

  • beta cell

  • middle temporal gyrus

  • Brodmann area 10
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • habenula

  • pineal gland

  • neural layer of retina

  • islet of Langerhans

  • retinal pigment epithelium

  • epithelium of lens

  • deep cerebellar nuclei

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4760

18012

Ensembl

ENSG00000162992

ENSMUSG00000034701

UniProt

Q13562

Q60867

RefSeq (mRNA)

NM_002500

NM_010894

RefSeq (protein)

NP_002491

NP_035024

Location (UCSC)Chr 2: 181.67 – 181.68 MbChr 2: 79.28 – 79.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurogenic differentiation 1 (Neurod1), also calledβ2,[5] is atranscription factor of theNeuroD-type. It is encoded by the human geneNEUROD1.

In mice,Neurod1 expression is first seen at embryonic day 12 (E12).[6]

It is a member of the Neurod family ofbasic helix-loop-helix (bHLH)transcription factors, composed of Neurod1,Neurod2,Neurod4, andNeurod6. The protein formsheterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as theE-box. It regulates expression of theinsulin gene, and mutations in this gene result intype II diabetes mellitus in mouse models and in human clinical patients.[7]

Neurod1 is found to convert reactiveglial cells into functionalneurons in the mouse brainin vivo[8] In the adultcortex,Neurod1 expression is a marker of mature excitatorypyramidal neurons in the upper-most layers of the cortex.[9]

Interactions

[edit]

Neurod1 has been shown tointeract withMAP3K10,[10]MAFA[11] andCyclin D1.[12]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000162992Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000034701Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Poulin G, Turgeon B, Drouin J (November 1997)."NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene".Molecular and Cellular Biology.17 (11):6673–6682.doi:10.1128/mcb.17.11.6673.PMC 232521.PMID 9343431.
  6. ^Bormuth I, Yan K, Yonemasu T, Gummert M, Zhang M, Wichert S, et al. (January 2013)."Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions".The Journal of Neuroscience.33 (2):641–651.doi:10.1523/JNEUROSCI.0899-12.2013.PMC 6704922.PMID 23303943.S2CID 25600245.
  7. ^Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, et al. (November 1999). "Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus".Nature Genetics.23 (3):323–328.doi:10.1038/15500.PMID 10545951.S2CID 3216136.
  8. ^Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G (February 2014)."In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model".Cell Stem Cell.14 (2):188–202.doi:10.1016/j.stem.2013.12.001.PMC 3967760.PMID 24360883.
  9. ^Tutukova S, Tarabykin V, Hernandez-Miranda LR (2021)."The Role of Neurod Genes in Brain Development, Function, and Disease".Frontiers in Molecular Neuroscience.14 662774.doi:10.3389/fnmol.2021.662774.PMC 8221396.PMID 34177462.
  10. ^Marcora E, Gowan K, Lee JE (August 2003)."Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2".Proceedings of the National Academy of Sciences of the United States of America.100 (16):9578–9583.Bibcode:2003PNAS..100.9578M.doi:10.1073/pnas.1133382100.PMC 170960.PMID 12881483.
  11. ^Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, et al. (March 2005)."The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription".The Journal of Biological Chemistry.280 (12):11887–11894.doi:10.1074/jbc.M409475200.PMID 15665000.
  12. ^Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002)."Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD".The Journal of Biological Chemistry.277 (11):8847–8853.doi:10.1074/jbc.M110747200.PMID 11788592.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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