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| Formula | C24H23Cl3N4O |
| Molar mass | 489.83 g·mol−1 |
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NESS-0327 is a drug used in scientific research which acts as an extremely potent and selectiveantagonist of thecannabinoid receptorCB1. It is much more potent an antagonist, and more selective for the CB1 receptor over CB2, than the more commonly used ligandrimonabant, with aKi at CB1 of 350fM (i.e. 0.00035nM) and a selectivity of over 60,000x for CB1 over CB2.[1]Independently, two other groups have described only modest nanomolar CB1 affinity for this compound (125nM[2] and18.4nM[3]).Also unlike rimonabant, NESS-0327 does not appear to act as aninverse agonist at higher doses, instead being a purelyneutral antagonist which blocks the CB1 receptor but does not produce any physiological effect of its own.[4]
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