Movatterモバイル変換

[0]ホーム

Jump to content

5′-(N-Ethylcarboxamido)adenosine

中文

Edit links

From Wikipedia, the free encyclopedia

(Redirected fromNECA (drug))

5'-(N-Ethylcarboxamido)adenosine
Names

IUPAC name (2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Other names 5'-Ethylcarboxamido adenosine; NECA
Identifiers
CAS Number	35920-39-9^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:73284
ChEMBL	ChEMBL464859
ChemSpider	395094
ECHA InfoCard	100.164.621
EC Number	636-060-5
IUPHAR/BPS	377
PubChem CID	448222
UNII	3WC8SJ5ZLJ
CompTox Dashboard(EPA)	DTXSID801017234
InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1 Key: JADDQZYHOWSFJD-FLNNQWSLSA-N
SMILES CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O
Properties
Chemical formula	C₁₂H₁₆N₆O₄
Molar mass	308.298 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

5'-(N-Ethylcarboxamido)adenosine (NECA) is anucleoside that is a non-selectiveadenosine receptor agonist.^[1] It has been used as a biochemical tool in the study of the function of adenosine receptors.^[2]

References

[edit]

^Cristalli, Gloria; Lambertucci, Catia; Taffi, Sara; Vittori, Sauro; Volpini, Rosaria (2003). "Medicinal Chemistry of Adenosine A2A Receptor Agonists".Current Topics in Medicinal Chemistry.3 (4):387–401.doi:10.2174/1568026033392282.PMID 12570757.
^Schwabe, U.; Lorenzen, A.; Grün, S. (1991). "Adenosine receptors in the central nervous system".Recent Advances in Neuropharmacology. pp. 149–155.doi:10.1007/978-3-7091-9175-0_19.ISBN 978-3-211-82300-2.PMID 1817158.

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others

Others

Others:Chrysophanol (rhubarb)

See also:Receptor/signaling modulators

This article about acarbohydrate is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=5′-(N-Ethylcarboxamido)adenosine&oldid=1318139994"

Categories:

Hidden categories:

[8]ページ先頭